Effect of Permeation Enhancers on the Penetration Mechanism of Transfersomal Gel of Ketoconazole.

Effect of permeation enhancers on the penetration mechanism of transfersomal gel of ketoconazole.

Filed under: Drug and Alcohol Rehabilitation

J Adv Pharm Technol Res. 2012 Apr; 3(2): 112-6
Rajan R, Vasudevan DT

The aim of the present research work was to investigate the potential of transfersome formulations for transdermal delivery of Ketoconazole (KTZ). KTZ is a broad-spectrum antifungal agent that is active against a wide variety of fungi and yeasts. It is readily but incompletely absorbed after oral dosing and is highly variable. The transfersomes were formulated by lipid film hydration technique using Rotary vacuum Evaporator. The prepared transfersomes were converted into suitable gel formulation and is evaluated for their gel characteristics like pH, viscosity, spreadability, extrudability, homogeneity, drug content, etc. Suitable essential oils acting as natural permeation enhancers were added to the transfersomal formulation of KTZ for their release studies. Studies proved that addition of suitable permeation enhancers to the transfersomal formulation improved the release and permeation of KTZ, which showed that the permeation enhancers modify the barrier to penetration present in skin without itself undergoing any change. From the various essential oils which are used as permeation enhancers, the formulation containing Eucalyptus oil showed better in vitro release and permeation as compared with other formulations containing different permeation enhancers.
HubMed – drug


Effect of hydroxyapatite on the physicochemical characteristics of a gentamicin-loaded monoolein gel intended to treat chronic osteomyelitis.

Filed under: Drug and Alcohol Rehabilitation

J Adv Pharm Technol Res. 2012 Apr; 3(2): 100-5
Semdé R, Gondi RF, Sombié BC, Yaméogo BG, Ouédraogo M

Many works have demonstrated the real potential of gentamicin-monoolein-water formulations as bioresorbable and sustained-release implants for the local treatment of the chronic osteomyelitis. In order to improve the efficacy of this type of implant, the incorporation of hydroxyapatite, a well-known osteointegrator material, is thought to be an interesting approach. Five formulations incorporating 0, 2.5, 5, 10, and 20% of hydroxyapatite were examined with regard to their physicochemical and in vitro drug release characteristics. The rheological, thermal (differential scanning calorimetric and thermogravimetric diffraction analysis), X-ray diffraction, and dissolution studies have showed that the presence of hydroxyapatite does not dramatically disturb the cubic liquid crystalline structure of the monoolein-water gel and their ability to progressively release the antibiotic. Implant 20% that was capable to release gentamicin sulfate over a period of four weeks without marked burst effect could be used as a more suitable biodegradable delivery system for the local management of chronic osteomyelitis.
HubMed – drug


Herbal drug development from natural sources.

Filed under: Drug and Alcohol Rehabilitation

J Adv Pharm Technol Res. 2012 Apr; 3(2): 82
Sardana S

HubMed – drug


Guidelines regarding management of adrenal insufficiency in the Holy month of Ramadan.

Filed under: Drug and Alcohol Rehabilitation

Indian J Endocrinol Metab. 2012 Jul; 16(4): 519-21
Siddiqi SS, Singh SK, Khan SA, Ishtiaq O, Pathan MF, Raza SA, Khan AK, Zargar AH, Bantwal G

Adrenal insufficiency is a life-threatening event, so it is recommended for patients with known adrenal insufficiency to be properly educated regarding sick-day management. In the month of Ramadan, people refrain from eating and drinking during daylight hours. It is very important for patients with adrenal insufficiency, who wish to keep a fast, to be well aware of the disease, the suitable drug to be used for that particular period, warning signs, sick-day management, physical activity, and dietary limits. This article describes guidelines for the sick-day management of patients with adrenal insufficiency, in the month of Ramadan.
HubMed – drug


Diabetic emergencies including hypoglycemia during Ramadan.

Filed under: Drug and Alcohol Rehabilitation

Indian J Endocrinol Metab. 2012 Jul; 16(4): 512-5
Ahmad J, Pathan MF, Jaleel MA, Fathima FN, Raza SA, Khan AK, Ishtiaq O, Sheikh A

Majority of physicians are of the opinion that Ramadan fasting is acceptable for well-balanced type 2 patients conscious of their disease and compliant with their diet and drug intake. Fasting during Ramadan for patients with diabetes carries a risk of an assortment of complications. Islamic rules allow patients not to fast. However, if patient with diabetes wish to fast, it is necessary to advice them to undertake regular monitoring of blood glucose levels several times a day, to reduce the risk of hypoglycemia during day time fasting or hyperglycemia during the night. Patient with type 1 diabetes who fast during Ramadan may be better managed with fast-acting insulin. They should have basic knowledge of carbohydrate metabolism, the standard principles of diabetes care, and pharmacology of various antidiabetic drugs. This Consensus Statement describes the management of the various diabetic emergencies that may occur during Ramadan.
HubMed – drug



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Keeping prescription drug use under control

Filed under: Drug and Alcohol Rehabilitation

Many addicts began using medications legitimately but using them other than as prescribed led to abuse, however, with treatment, an addict can recover and live a full life. … Symposium presenter, Dr. Elinore McCance-Katz, MD, PhD, state medical …
Read more on Inyo Register


Melanie Griffith Returns To Theater, Says Daughters Helped Her Overcome

Filed under: Drug and Alcohol Rehabilitation

Battles with drugs and alcohol have long plagued Melanie Griffith, but the actress, who returned to the stage Sunday for a week-long stint in "No Way Around But Through" in Burbank, Calif., said it was her two daughters who helped her overcome her …
Read more on International Business Times


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