Effect of Anthralin on Cell Viability in Human Prostate Adenocarcinoma.

Effect of anthralin on cell viability in human prostate adenocarcinoma.

Filed under: Drug and Alcohol Rehabilitation

Bull Exp Biol Med. 2012 Jul; 153(3): 361-3
Raevskaya AA, Gorbunova SL, Savvateeva MV, Severin SE, Kirpichnikov MP

The study revealed the key role of serine protease hepsin activity in transition of in situ prostate adenocarcinoma into the metastasizing form. Inhibition of hepsin activity suppresses the invasive growth of the tumor. Hepsin is an convenient target for pharmacological agents, so the study of its inhibitory mechanisms is a promising avenue in drug development. Assay of proteolytic activity in various tumor cell lines in vitro showed that this activity in prostate adenocarcinoma cells significantly surpasses proteolytic activity in other examined tumor cell lines. Selective cytotoxic action of anthralin, an inhibitor of hepsin activity, on human adenocarcinoma cells was demonstrated in comparison with other tumor cell lines.
HubMed – drug


Effects of Fatty acids on human serum albumin binding centers.

Filed under: Drug and Alcohol Rehabilitation

Bull Exp Biol Med. 2012 Jul; 153(3): 323-6
Dobretsov GE, Syrejshchikova TI, Smolina NV, Uzbekov MG

Albumin is a carrier of nonesterified long-chain fatty acids and many other ligands. The status of its binding centers was studied for various proportions of nonesterified long-chain fatty acids and albumin as exemplified by palmitic acid. The status of the binding center was tested by recording K-35 probe fluorescence decay in the subnanosecond band. This method showed the work of three types of centers. Palmitic acid enhanced binding activity of all centers, though to a different degree: if the palmitic acid/albumin proportion increased to 2-3, the probe binding to type 1 centers (located in the drug center I region) increased 1.5 times, while binding to type 3 centers increased more than 3-fold. Modification of these centers by nonesterified long-chain fatty acids was similar in the isolated human albumin preparation and in diluted blood serum. Hence, K-35 probe showed the actual status of various albumin centers, their binding capacity depending to a different measure on the fatty acid charge of albumin.
HubMed – drug


Non-steroidal anti-inflammatory drug-induced enteropathy.

Filed under: Drug and Alcohol Rehabilitation

Clin Endosc. 2012 Jun; 45(2): 138-44
Lim YJ, Yang CH

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed drugs in the world. NSAID-induced lower gastrointestinal (GI) complications are increasing while upper GI complications are decreasing. Lower GI events accounted for 40% of all serious GI events in patients on NSAIDs. Capsule endoscopy and device assisted enteroscopy are available for detection of small intestinal lesions. Capsule endoscopy studies have demonstrated that NSAIDs use in healthy volunteers raised the incidence (55% to 75%) of intestinal damage. It appears that selective cyclooxygenase-2 inhibitors (coxibs) improved upper and lower GI safety based on results of clinical trials. Selective coxibs are still capable of triggering GI adverse events and cardiovascular toxicity issues were the main focus of concerns. Unfortunately, definite strategies are not available to prevent or heal NSAID-induced intestinal injuries. Thus, there is still a strong clinical need for effective drugs with improved safety profiles than the existing NSAIDs.
HubMed – drug


Normal tissue protection for improving radiotherapy: Where are the Gaps?

Filed under: Drug and Alcohol Rehabilitation

Transl Cancer Res. 2012 Jun; 1(1): 35-48
Prasanna PG, Stone HB, Wong RS, Capala J, Bernhard EJ, Vikram B, Coleman CN

Any tumor could be controlled by radiation therapy if sufficient dose were delivered to all tumor cells. Although technological advances in physical treatment delivery have been developed to allow more radiation dose conformity, normal tissues are invariably included in any radiation field within the tumor volume and also as part of the exit and entrance doses relevant for particle therapy. Mechanisms of normal tissue injury and related biomarkers are now being investigated, facilitating the discovery and development of a next generation of radiation protectors and mitigators. Bringing recent research advances stimulated by development of radiation countermeasures for mass casualties, to clinical cancer care requires understanding the impact of protectors and mitigators on tumor response. These may include treatments that modify cellular damage and death processes, inflammation, alteration of normal flora, wound healing, tissue regeneration and others, specifically to counter cancer site-specific adverse effects to improve outcome of radiation therapy. Such advances in knowledge of tissue and organ biology, mechanisms of injury, development of predictive biomarkers and mechanisms of radioprotection have re-energized the field of normal tissue protection and mitigation. Since various factors, including organ sensitivity to radiation, cellular turnover rate, and differences in mechanisms of injury manifestation and damage response vary among tissues, successful development of radioprotectors/mitigators/treatments may require multiple approaches to address cancer site specific needs. In this review, we discuss examples of important adverse effects of radiotherapy (acute and intermediate to late occurring, when it is delivered either alone or in conjunction with chemotherapy, and important limitations in the current approaches of using radioprotectors and/or mitigators for improving radiation therapy. Also, we are providing general concepts for drug development for improving radiation therapy.
HubMed – drug



AA&D Success Story – Mike – Mike shares his experience with the Attacking Anxiety and Depression program. Mike suffered from debilitating panic attacks and depression. “I was in the Marine Corps. I was self-medicating for my problems. I had a lot of issues, things I didn’t know how to deal with. I tried to stop self-medicating on my own and I couldn’t. I was a self-referral into a drug and alcohol rehabilitation program. It basically cost me my military career because it didn’t work out well. As a result of this program — after two suicide attempts, drug and alcohol rehabilitation, being hospitalized — now I’m drug and alcohol free.”


A Collaboration of Behavioral Health Care Plus Addiction Treatment is a

Filed under: Drug and Alcohol Rehabilitation

Care Plus NJ, Inc. (a behavioral health and primary care center headquartered in Paramus) and Turning Point (a drug and alcohol addiction treatment center headquartered in Paterson) are now offering collaborative treatment and referral services for …
Read more on ParamusPost.com


Youth drug court victim of budget cuts, say Salvos

Filed under: Drug and Alcohol Rehabilitation

THE head of the Salvation Army unit involved in the Youth Drug and Alcohol Court has accused the government of dishonesty in its use of figures that purport to show the court is a failure. John Drew, the general manager of the army's Youthlink service …
Read more on Sydney Morning Herald


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