Eating Disorders: Screening for Impulse Control Symptoms in Patients With De Novo Parkinson Disease: A Case-Control Study.

Screening for impulse control symptoms in patients with de novo Parkinson disease: A case-control study.

Filed under: Eating Disorders

Neurology. 2013 Jan 8; 80(2): 176-180
Weintraub D, Papay K, Siderowf A,

OBJECTIVE: To determine the frequency and correlates of impulse control and related behavior symptoms in patients with de novo, untreated Parkinson disease (PD) and healthy controls (HCs). METHODS: The Parkinson’s Progression Markers Initiative is an international, multisite, case-control clinical study conducted at 21 academic movement disorders centers. Participants were recently diagnosed, untreated PD patients (n = 168) and HCs (n = 143). The outcome measures were presence of current impulse control and related behavior symptoms based on recommended cutoff points for the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease (QUIP)-Short Form. RESULTS: There were 311 participants with complete QUIP data. Frequencies of impulse control and related behavior symptoms for patients with PD vs HCs were as follows: gambling (1.2% vs 0.7%), buying (3.0% vs 2.1%), sexual behavior (4.2% vs 3.5%), eating (7.1% vs 10.5%), punding (4.8% vs 2.1%), hobbyism (5.4% vs 11.9%), walkabout (0.6% vs 0.7%), and any impulse control or related behavior (18.5% vs 20.3%). In multivariable models, a diagnosis of PD was not associated with symptoms of any impulse control or related behavior (p ? 0.10 in all cases). CONCLUSIONS: PD itself does not seem to confer an increased risk for development of impulse control or related behavior symptoms, which further reinforces the reported association between PD medications and impulse control disorders in PD. Given that approximately 20% of patients with newly diagnosed PD report some impulse control or related behavior symptoms, long-term follow-up is needed to determine whether such patients are at increased risk for impulse control disorder development once PD medications are initiated.
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External influences on children’s self-served portions at meals.

Filed under: Eating Disorders

Int J Obes (Lond). 2013 Jan 8;
Fisher JO, Birch LL, Zhang J, Grusak MA, Hughes SO

OBJECTIVE:Large portions promote intake among children, but little is known about the external influences of the eating environment on children’s self-selected portion sizes. This research experimentally tested effects of the amount of entree available and serving spoon size on children’s self-served entree portions and intakes at dinner meals. A secondary objective was to identify child and family predictors of self-served entree portion sizes.DESIGN:A 2 × 2 within-subjects design was used, in which the amount of a pasta entree available for self-serving (275 vs 550?g) and the serving spoon size (teaspoon vs tablespoon) were systematically varied. The serving bowl size and portion sizes of all other foods offered were held constant across conditions. Conditions were spaced 1 week apart and randomly assigned. Weighed self-served entree portions and food intakes as well as demographics, maternal feeding styles and child/maternal anthropometrics were measured.SUBJECTS:Participants were 60 ethnically diverse children aged 4-6 years and their mothers.RESULTS:Mixed models revealed that children served themselves 40% more entree when the amount available was doubled (P<0.0001) and 13% more when the serving spoon size was tripled (P<0.05). Serving spoon size and the amount of entree available indirectly influenced children's intake, with larger self-served portion sizes related to greater entree intakes (P<0.0001). Greater self-served portions and energy intakes at the meal were seen among those children whose mothers reported indulgent or authoritarian feeding styles (P<0.001).CONCLUSION:Children's self-served portion sizes at meals are influenced by size-related facets of the eating environment and reflect maternal feeding styles.International Journal of Obesity advance online publication, 8 January 2013; doi:10.1038/ijo.2012.216. HubMed – eating


Exploring the association of psychological status with self-rated diabetes control: results from the montreal evaluation of diabetes treatment study.

Filed under: Eating Disorders

Psychosomatics. 2013 Jan; 54(1): 35-43
Smith KJ, Gariépy G, Pedneault M, Beland M, Clyde M, Schmitz N

There is an increasing interest in single-item self-rated indicators of perceived health and control status in people with chronic illnesses such as diabetes. However, self-rated measures can be associated with indicators of psychological status. The aim of this paper is to explore the association of anxiety, depression, and diabetes distress with self-rated diabetes control.Telephone interviews were conducted with 1,787 people with type 2 diabetes taking oral hypoglycemic medication. Diabetes control, health behaviors, and outcomes, anxiety, depression, and diabetes distress were assessed by standardized questionnaires. Self-reported diabetes control was modeled using logistic regression.The best fit logistic regression model for self-rated poor diabetes control was a model that incorporated diabetes distress. When adjusted for age, sex, and all other health behaviors and outcomes, poor diabetes control was most associated with diabetes distress, physical inactivity, being overweight, and poor eating habits.Results from this study indicate that poor self-rated diabetes control shares the strongest associations with diabetes-specific distress along with perceptions of diabetes-specific healthcare behaviors and outcomes.
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Quantification of clenbuterol at trace level in human urine by ultra-high pressure liquid chromatography-tandem mass spectrometry.

Filed under: Eating Disorders

J Chromatogr A. 2012 Dec 19;
Nicoli R, Petrou M, Badoud F, Dvorak J, Saugy M, Baume N

Clenbuterol is a ?2 agonist agent with anabolic properties given by the increase in the muscular mass in parallel to the decrease of the body fat. For this reason, the use of clenbuterol is forbidden by the World Anti-Doping Agency (WADA) in the practice of sport. This compound is of particular interest for anti-doping authorities and WADA-accredited laboratories due to the recent reporting of risk of unintentional doping following the eating of meat contaminated with traces of clenbuterol in some countries. In this work, the development and the validation of an ultra-high pressure liquid chromatography coupled to electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS) method for the quantification of clenbuterol in human urine is described. The analyte was extracted from urine samples by liquid-liquid extraction (LLE) in basic conditions using tert butyl-methyl ether (TBME) and analyzed by UHPLC-MS/MS with a linear gradient of acetonitrile in 9min only. The simple and rapid method presented here was validated in compliance with authority guidelines and showed a limit of quantification at 5pg/mL and a linearity range from 5pg/mL to 300pg/mL. Good trueness (85.8-105%), repeatability (5.7-10.6% RSD) and intermediate precision (5.9-14.9% RSD) results were obtained. The method was then applied to real samples from eighteen volunteers collecting urines after single oral doses administration (1, 5 and 10?g) of clenbuterol-enriched yogurts.
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