Drug and Alcohol Rehabilitation: Substance Abuse Treatment, HIV/AIDS, and the Continuum of Response for People Who Inject Drugs.

Substance Abuse Treatment, HIV/AIDS, and the Continuum of Response for People Who Inject Drugs.

Filed under: Drug and Alcohol Rehabilitation

Adv Prev Med. 2012; 2012: 541489
Kresina TF, Lubran R, Clark HW, Cheever LW

The continuum of response (CoR) to HIV/AIDS is a framework for implementation of HIV prevention, care, and treatment programs based on a national strategic plan for HIV/AIDS services. The CoR for people who inject drugs (PWID) is an important extension of the developed CoR to HIV/AIDS. The CoR-PWID employs stakeholders who together plan, develop, pilot, and provide a full range of services that address the various prevention, care/support, and treatment needs of people, families, and communities infected or affected by HIV/AIDS and injection drug use. The CoR-PWID comprises a broad range of services that include but are not limited to the World Health Organization priority interventions for HIV/AIDS prevention, treatment, and care in the health sector and the package of essential interventions for the prevention, treatment, and care of HIV for people who inject drugs. Implementation of these well-defined, essential prevention, care/support, and treatment services, in addition to locally defined needed services, in a coordinated fashion is important to clients, their families, and communities. The CoR-PWID is, therefore, a necessary framework essential for service development for countries that address HIV/AIDS in populations of PWID.
HubMed – drug


Evidences For Charge Transfer-Induced Conformational Changes In Carbon Nanostructure-Protein Corona.

Filed under: Drug and Alcohol Rehabilitation

J Phys Chem C Nanomater Interfaces. 2012 Oct 18; 116(41): 22098-22103
Podila R, Vedantam P, Ke PC, Brown JM, Rao AM

The binding of proteins to a nanostructure often alters protein secondary and tertiary structures. However, the main physical mechanisms that elicit protein conformational changes in the presence of the nanostructure have not yet been fully established. Here we performed a comprehensive spectroscopic study to probe the interactions between bovine serum albumin (BSA) and carbon-based nanostructures of graphene and single-walled carbon nanotubes (SWNTs). Our results showed that the BSA “corona” acted as a weak acceptor to facilitate charge transfer from the carbon nanostructures. Notably, we observed that charge transfer occurred only in the case of SWNTs but not in graphene, resulting from the sharp and discrete electronic density of states of the former. Furthermore, the relaxation of external ?-helices in BSA secondary structure increased concomitantly with the charge transfer. These results may help guide controlled nanostructure-biomolecular interactions and prove beneficial for developing novel drug delivery systems, biomedical devices and engineering of safe nanomaterials.
HubMed – drug


Cyclodextrin-based nanosponges as drug carriers.

Filed under: Drug and Alcohol Rehabilitation

Beilstein J Org Chem. 2012; 8: 2091-9
Trotta F, Zanetti M, Cavalli R

Cyclodextrin-based nanosponges, which are proposed as a new nanosized delivery system, are innovative cross-linked cyclodextrin polymers nanostructured within a three-dimensional network. This type of cyclodextrin polymer can form porous insoluble nanoparticles with a crystalline or amorphous structure and spherical shape or swelling properties. The polarity and dimension of the polymer mesh can be easily tuned by varying the type of cross-linker and degree of cross-linking. Nanosponge functionalisation for site-specific targeting can be achieved by conjugating various ligands on their surface. They are a safe and biodegradable material with negligible toxicity on cell cultures and are well-tolerated after injection in mice. Cyclodextrin-based nanosponges can form complexes with different types of lipophilic or hydrophilic molecules. The release of the entrapped molecules can be varied by modifying the structure to achieve prolonged release kinetics or a faster release. The nanosponges could be used to improve the aqueous solubility of poorly water-soluble molecules, protect degradable substances, obtain sustained delivery systems or design innovative drug carriers for nanomedicine.
HubMed – drug



Staff Bio – Erin G. Las Vegas Drug and Alcohol rehab, call (702) 228-8520 – Erin Grissman speaks about her position and experiences at Solutions Recovery, Inc. a drug and alcohol rehabilitation center. To find out more about addictions and how to treat them visit our website at www.solutions-recovery.com


Find More Drug And Alcohol Rehabilitation Information…