Drug and Alcohol Rehabilitation: Stent Thrombosis: Incidence, Predictors and New Technologies.

Stent thrombosis: incidence, predictors and new technologies.

Filed under: Drug and Alcohol Rehabilitation

Thrombosis. 2012; 2012: 956962
Buchanan GL, Basavarajaiah S, Chieffo A

Some concerns have been raised regarding the risk of late and very late stent thrombosis (ST) following drug-eluting stent implantation. Despite remaining an uncommon complication of percutaneous coronary intervention, when ST occurs, it can be catastrophic to the individual, commonly presenting as acute ST elevation myocardial infarction or sudden cardiac death. The incidence and predictors of ST have been reported in the literature and the role of dual antiplatelet therapies in the avoidance of such a complication remains vital. Ongoing studies are assessing the role of these therapies including platelet reactivity testing, genetic testing and optimum duration of therapy. In addition, newer polymer-free and bioabsorbable stents are under investigation in the quest to potentially minimise the risk of ST.
HubMed – drug


Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier.

Filed under: Drug and Alcohol Rehabilitation

Polymers (Basel). 2011 Sep 1; 3(3): 1377-1397
Makadia HK, Siegel SJ

In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications. PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer. In particular, PLGA has been extensively studied for the development of devices for controlled delivery of small molecule drugs, proteins and other macromolecules in commercial use and in research. This manuscript describes the various fabrication techniques for these devices and the factors affecting their degradation and drug release.
HubMed – drug


The predictive factors of recurrent deep vein thrombosis.

Filed under: Drug and Alcohol Rehabilitation

ARYA Atheroscler. 2011; 7(3): 123-8
Farzamnia H, Rabiei K, Sadeghi M, Roghani F

About 2-5% of people experience deep-vein thrombosis (DVT) during their lives. Death, disease recurrence, post-thrombotic syndrome, and excessive bleeding due to coagulant medications are among the most important DVT complications. Recent research found a high incidence of DVT recurrence after the first attack. Disease recurrence has a multifactorial pathogenesis and its probability is related with the number and severity of risk factors. The present study aimed to investigate DVT recurrence and the associated risk factors.This retrospective cross-sectional study evaluated all DVT patients hospitalized in Alzahra Hospital, Isfahan, Iran, during April 2000 to April 2011. The risk factors were obtained from patients’ records including smoking, intravenous drug abuse, having a history of surgery in last four weeks, immobility, obesity, history of cardiac disease, and cancer.A total number of 2550 DVT patients were hospitalized in Alzahra Hospital during the study period. It was only possible to extract the data from 385 patient records. A history of DVT was reported in 48 individuals (12.5%). The comparison between the risk factors in patients with a first time DVT and those experiencing a recurrent DVT revealed significant differences solely in the prevalence of blood disorders and immobility. Applying stepwise regression indicated immobility (OR: 4.57; 95% CI: 1.26-16.57; P < 0.021) and coagulopathy (OR: 0.33; 95% CI: 0.13-0.81; P < 0.016) with DVT recurrence.Based on our findings, DVT patients are suggested to be mobilized as soon as possible. In addition, they should be advised to increase their activity after discharge. HubMed – drug


Cytochrome P450 2C19 Polymorphism in Iranian Patients with Coronary Artery Disease.

Filed under: Drug and Alcohol Rehabilitation

ARYA Atheroscler. 2011; 7(3): 106-10
Akhlaghi A, Shirani S, Ziaie N, Pirhaji O, Yaran M, Shahverdi G, Sarrafzadegan N, Khosravi A, Khosravi E

The polymorphisms of cytochrome P450 2C19 (CYP2C19) gene are major prognostic factors for the response to clopidogrel therapy in patients with coronary artery diseases (CAD). The CYP2C19*2 is the most important allele responsible for resistance to clopidogrel therapy. This study examined CYP2C19 gene polymorphism (CYP2C19*1 and *2) in Iranian patients.This cross-sectional study was performed on 43 Iranian patients with CAD who underwent percutaneous coronary intervention (PCI) and received drug-eluted stents (DES). CYP2C19 polymorphisms were assessed using real time PCR and frequency of CYP2C19*1 and CYP2C19*2 were determined, and then homo- or heterozygous state of genes was detected by Melt Curve Analysis method.Forty three patients (mean age = 58.8 ± 10.0 years, 79.1% male) participated in this study. CYP2C19*1/CYP2C19*1 genotype was observed in 31 (72.1%) of participates, CYP2C19*1/CYP2C19*2 genotype in 10 (23.3%), and CYP2C19*2/CYP2C19*2 genotype in 2 patients (4.7%). The frequency of CYP2C19*2 allele in the sample was 27.9%.This study demonstrated a high prevalence of CYP2C19*2 gene polymorphism in Iranian patients. Further studies with larger samples or longitudinal are required to determine the effects of this polymorphism on the prognosis of CAD patients in our population.
HubMed – drug



4. Support the Cape Residential Drug and Alcohol Rehabilitation Centre – Please support the Cape Residential Drug and Alcohol Rehabilitation Centre. Ex-rehabilitation client and now gainfully employed community engagement worker, Bruce Adams from Mornington Island talks about his personal journey and the important role of alcohol and drug rehabilitation in assisting Indigenous people gain a better future and employment. His support for the development of the Cape Residential Drug and Alcohol Rehabilitation Centre outside of Cooktown is testament to the important role it will play in helping Indigenous people to reach their full potential and become active contributing members of society.


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