Drug and Alcohol Rehabilitation: Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enterovirus B and D by Targeting Viral Protein 2C.

Selective serotonin reuptake inhibitor fluoxetine inhibits replication of Human Enterovirus B and D by targeting viral protein 2C.

Filed under: Drug and Alcohol Rehabilitation

Antimicrob Agents Chemother. 2013 Jan 18;
Ulferts R, van der Linden L, Thibaut HJ, Lanke KH, Leyssen P, Coutard B, de Palma AM, Canard B, Neyts J, van Kuppeveld FJ

Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either treatment or prophylaxis of enterovirus infections. We report that fluoxetine (Prozac©) – a selective serotonin reuptake inhibitor – inhibits replication of human enterovirus (HEV)-B and HEV-D, but does not affect the replication of HEV-A and HEV-C or human rhinoviruses A and B. We show that fluoxetine interferes with viral RNA replication and we identified viral protein 2C as the target of this compound.
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