Drug and Alcohol Rehabilitation: Intradermal Needle-Free Powdered Drug Injection by a Helium-Powered Device.

Intradermal needle-free powdered drug injection by a helium-powered device.

Filed under: Drug and Alcohol Rehabilitation

Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012: 2068-71
Liu J, Hogan NC, Hunter IW

We present a new method for needle-free powdered drug injection via a bench-top gas-powered device. This injector provides an alternative method of vaccine delivery to address the cold chain problem-the cost and risk of transporting temperature sensitive vaccines to developing countries. The device houses interchangeable nozzle inserts to vary orifice geometries and is capable of delivering polymer beads (1-5 µm diameter) into the dermal layer of porcine tissue. Results for injection shape and injection depth versus nozzle orifice diameter demonstrate the device’s controllability.
HubMed – drug


A computational model of a controllable needle-free jet injector.

Filed under: Drug and Alcohol Rehabilitation

Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012: 2052-5
Williams RM, Hogan NC, Nielsen PM, Hunter IW, Taberner AJ

We present a mathematical model of the dynamics of a previously developed needle-free jet injector (NFJI) that is based upon a servo-controlled Lorentz-force motor. The injector creates a fluid jet that can pierce through the skin and deliver a drug to dermal, subcutaneous and muscular tissue. We use the model to predict the jet speed achieved during an injection. The model simulates the electrical response of the motor coil, the mechanical response of the drug piston and ampoule and the friction incident upon the piston during the time course of the injection. High-speed video measurements of piston movement in response to a step input show that the model predicts piston-tip position during an injection within an RMS error of 287 µm. The corresponding jet speed is predicted to be 180 m·s(-1) with a maximum overshoot to 205 m·s(-1).
HubMed – drug


High-efficiency wireless power delivery for medical implants using hybrid coils.

Filed under: Drug and Alcohol Rehabilitation

Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012: 1683-6
Artan NS, Patel RC, Ning C, Chao HJ

With the exciting developments in the implant technology allowing sophisticated signal processing, stimulation, and drug delivery capabilities, there is new hope for many patients of epilepsy, Parkinson’s disease, and stroke to improve their quality of life. Such implants require high power to deliver the promised rich functionality. Yet, delivering high power to implants without damaging the tissue due to heating while keeping the implant footprint small is a challenge. In this paper, we propose a hybrid multi-layer coil as the secondary coil to provide a power and space-efficient solution. The proposed coils can deliver power to an implant for long durations without increasing the skin temperature over 1C.
HubMed – drug


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