Drug and Alcohol Rehabilitation: In Vitro Evaluation of Moringa Oleifera Gum for Colon-Specific Drug Delivery.

In vitro evaluation of Moringa oleifera gum for colon-specific drug delivery.

Filed under: Drug and Alcohol Rehabilitation

Int J Pharm Investig. 2012 Jan; 2(1): 48-51
Singhal AK, Jarald EE, Showkat A, Daud A

Moringa gum obtained from stem of the plant Moringa oleifera Lam. belonging to family Moringaceae. Number of naturally occurring polysaccharides obtained from plant (guar gum, inulin), animal (chitosan, chondrotin sulphate), algal (alginates) or microbial (dextran) origin.The present study was evaluated Moringa oleifera gum as a carrier for colon specific drug delivery using in vitro drug release studies.Six formulations of curcumin were prepared using varying concentration of Moringa oleifera gum containing 50 mg curcumin by wet granulation method. Tablets were subjected for evaluation by studying the parameter like hardness, friability, drug content uniformity and in vitro drug release study. Hardness was found to be in the range of 5.5 to 7.3 kg/cm(2), the percentage friability was in the range of 0.60 to 0.89%, and tablet showed 98.99% to 99.89% of the labeled amount of curcumin indicating uniformity in drug content.In vitro drug release study was performed using simulated stomach, intestinal and colonic fluid. The susceptibility of Moringa gum to colonic bacteria was also assessed using drug release study with rat caecal contents. 30% Moringa gum containing formulation (F-3) was shown better drug released that is 90.46%, at the end of 24 h of dissolution study in the presence of rat caecal contents in comparison to 40% Moringa gum containing formulation (F-4) that was 78.03%.The results illustrate the usefulness of Moringa olefera gum as a potential carrier for colon-specific drug delivery.
HubMed – drug


Dissolution enhancement of glimepiride using modified gum karaya as a carrier.

Filed under: Drug and Alcohol Rehabilitation

Int J Pharm Investig. 2012 Jan; 2(1): 42-7
Nagpal M, Rajera R, Nagpal K, Rakha P, Singh S, Mishra D

The aim of present investigation is to enhance in vitro dissolution of poorly soluble drug glimepiride by preparing solid dispersions using modified gum karaya.Solid dispersions of drug were prepared by solvent evaporation method using modified gum karaya as carrier. Four batches of solid dispersion (SD1, SD4, SD9, and SD14) and physical mixture (PM1, PM4, PM9, and PM14) were prepared and characterized by differential scanning colorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, powder X-Ray diffraction (X-RD), and scanning electron microscopy (SEM) studies. Equilibrium solubility studies were carried out in shaker incubator for 24 h and in vitro drug release was determined using USP Dissolution Apparatus-II.Maximum solubility and in vitro dissolution were observed with Batch SD4. No significant enhancement of dissolution characteristics were observed in the corresponding physical mixture PM4. Low viscosity with comparable swelling characteristics as compared to GK of modified form of gum karaya may lead to improvement in dissolution behavior of solid dispersion batches. Also, the conversion of crystalline form of drug to amorphous form may be a responsible factor, which was further confirmed by DSC, FTIR studies, and X-RD studies. SEM photographs of batch SD4 revealed porous nature of particle surface.Modified forms of natural carriers prove beneficial in dissolution enhancement of poorly soluble drugs and exhibited a great potential in novel drug delivery systems.
HubMed – drug


Formulation and optimization of mucoadhesive bilayer buccal tablets of atenolol using simplex design method.

Filed under: Drug and Alcohol Rehabilitation

Int J Pharm Investig. 2012 Jan; 2(1): 34-41
Shirsand S, Suresh S, Keshavshetti G, Swamy P, Reddy PV

In the present study, mucoadhesive buccal bilayer tablets of atenolol were fabricated with the objective of avoiding first pass metabolism and to improve its bioavailability with reduction in dosing frequency. Hence, the aim of this work was to design oral controlled release mucoadhesive tablets of atenolol and to optimize the drug release profile and bioadhesion.Bilayer buccal tablets of atenolol were prepared by direct compression method using simplex method of optimization to investigate the combined effect of hydroxypropyl methylcellulose 15 cps (X(1)), Carbopol (X(2)) and mannitol (X(3)); the in vitro drug release (Y(1)) and mucoadhesive strength (Y(2)) were taken as responses. The designed tablets were evaluated for various physical and biological parameters like drug content uniformity, in vitro drug release, short-term stability, and drug- excipient interactions (FTIR).The formulation C containing hydroxypropyl methylcellulose 15 cps (10% w/w of matrix layer), Carbopol 934p (10% w/w of matrix layer) and mannitol (channeling agent, 40% w/w of matrix layer) was found to be promising. This formulation exhibited an in vitro drug release of 89.43% in 9 h along with satisfactory bioadhesion strength (7.20 g). Short-term stability studies on the promising formulation indicated that there are no significant changes in drug content and in vitro dissolution characteristics (P<0.05). IR spectroscopic studies indicated that there are no drug-excipient interactions. HubMed – drug


Design, evaluation and in vitro – in vivo correlation of glibenclamide buccoadhesive films.

Filed under: Drug and Alcohol Rehabilitation

Int J Pharm Investig. 2012 Jan; 2(1): 26-33
Prasanna RI, Sankari KU

Glibenclamide (G) is a popular anti-diabetic drug, belonging to the class of sulfonylurea. The drug is widely used for treating type II diabetes but it undergoes first-pass effect. A novel aspiration in treatment of diabetes, to provide greater therapeutic effect, bypass first pass effect and to improve patient compliance upon administering buccal drug delivery of Glibenclamide (G) have not been tested literally. Hence, the present study was designed to develop the buccal mucoadhesive films of glibenclamide by solvent casting technique; that is by using different polymers such as Hydroxy Propyl Methyl Cellulose 15 cps (HPMC), carbopol (CP), and poly vinyl pyrrolidone. Propylene glycol, which served the purpose of plasticizer as well as penetration enhancer and the backing membrane used was aluminium foil.The films were subjected to physicochemical parameters, in-vitro drug release and ex vivo bucco adhesive strength.The satisfactory results were obtained in all prepared formulation and based on the results G14 [HPMC (150 mg) + CP(20 mg) + PVP (30 mg)] was the best one compared to others. The drug release of all formulation follows zero order kinetics by diffusion mechanism of non-fickian diffusion type. Ex vivo, buccal permeation studies by using sheep buccal mucosa and finally stability studies by using human saliva were carried out for the optimized formulation G14.Good correlation was observed between in-vitro and in vivo correlation, thus revealing the ability of the formulation to reproduce the in-vitro release pattern through the in vivo.Glibenclamide muck-adhesive buccal films could be promising one as they, increase bioavailability by bypassing the first pass effect, minimize the dose, reduces the side effects, and improve patient compliance and also glibenclamide might be a right and suitable candidate for oral controlled drug delivery via buccoadhesive films.
HubMed – drug


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