Drug and Alcohol Rehabilitation: Improvement in Solubility of Poor Water-Soluble Drugs by Solid Dispersion.

Improvement in solubility of poor water-soluble drugs by solid dispersion.

Filed under: Drug and Alcohol Rehabilitation

Int J Pharm Investig. 2012 Jan; 2(1): 12-7
Sareen S, Mathew G, Joseph L

This article is intended to combine recent literature on solid dispersion technology for solubility enhancement with special emphasis on mechanism responsible for the same by solid dispersion, various preparation methods, and evaluation parameters. Solubility behavior is the most challenging aspect for various new chemical entities as 60% of the new potential products possess solubility problems. This is the biggest reason for new drug molecules not reaching to the market or not reaches to full potential. There are various techniques to enhance the drug solubility such as particle size reduction, nanosuspension, use of surfactants, salt formation, solid dispersion, etc. From this article it may be concluded that solid dispersion is an important approach for improvement of bioavailability of poor water-soluble drugs.
HubMed – drug


Drug delivery systems: An updated review.

Filed under: Drug and Alcohol Rehabilitation

Int J Pharm Investig. 2012 Jan; 2(1): 2-11
Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P, Bannerjee SK

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance. These routes provide promising alternatives to parenteral drug delivery particularly for peptide and protein therapeutics. For this purpose, several drug delivery systems have been formulated and are being investigated for nasal and pulmonary delivery. These include liposomes, proliposomes, microspheres, gels, prodrugs, cyclodextrins, among others. Nanoparticles composed of biodegradable polymers show assurance in fulfilling the stringent requirements placed on these delivery systems, such as ability to be transferred into an aerosol, stability against forces generated during aerosolization, biocompatibility, targeting of specific sites or cell populations in the lung, release of the drug in a predetermined manner, and degradation within an acceptable period of time.
HubMed – drug


Formulation and evaluation of mixed matrix gastro-retentive drug delivery for famotidine.

Filed under: Drug and Alcohol Rehabilitation

Int J Pharm Investig. 2011 Oct; 1(4): 247-54
Patel DM, Patel MJ, Patel AN, Patel CN

Present investigation describes an influence of ratio of Gelucire 43/01(hydrophobic) to hydroxypropyl methylcellulose K4M (HPMC K4M) (hydrophilic) and different fillers on release of famotidine from gastro-retentive tablets using 3(2) full factorial design. Ratio of Gelucire 43/01 to HPMC K4M (X(1)) and the type of filler (X(2)) were selected as independent variables while buoyancy lag time (BLT), drug release at 1h (Q(1)), 6h (Q(6)), and the 12h (Q(12)) were selected as dependent variables.Gastro-retentive tablets of famotidine were prepared by a solvent free melt granulation technique using Gelucire 43/01 as a hydrophobic meltable binder. HPMC K4M and sodium bicarbonate were used as matrixing agent and gas-generating agent, respectively. Prepared tablets were evaluated for in vitro dissolution, in vitro buoyancy, friability, hardness, drug content and weight variation. Dissolution data were fitted to various models to ascertain kinetics of drug release. The data were analyzed using regression analysis and analysis of variance.All formulations (F(1)-F(9)) showed floating within 3min and had total floating time of more than 12h. It was observed that a type of filler and the ratio of Gelucire 43/01 to HPMC K4M had significant influence on buoyancy lag time (P = 0.037) and Q(6) (P = 0.011), respectively without significant influence on Q(1) and Q(12).Formulation F(5) was selected as an optimum formulation as it showed more similarity in dissolution profile with theoretical profile (Similarity factor, f(2) = 83.01). The dissolution of batch F(5) can be described by zero order kinetics (r(2) = 0.9914) with anomalous (non-Fickian) diffusion as a release mechanism (n = 0.559). The difference observed in in vitro release profile after temperature sensitivity study at 40°C for 1 month was insignificant.
HubMed – drug



Does Drug Rehab Work? – Call (877) 446-1342 for a confidential consultation. We are a nationally recognized drug and alcohol treatment center committed to providing compassionate care to each of our patients. The Joint Commissions on Accreditations of Health Care Organizations has awarded The Treatment Center Gold Seal Accreditation for our superior quality of care in the substance abuse treatment centers field. Our staff is a team of highly trained, highly skilled addiction professionals who understand the complexities of addiction and treat the disease through contemporary methods. We offer the following services: • In-patient Drug and Alcohol Rehabilitation • Full Medical Drug and Alcohol Detox by Board Certified Physicians • Dual Diagnosis Substance Abuse Treatment • Individual and Group Therapy • Holistic Pain Treatment (following pain pill detox) • Acupuncture • Massage Therapy • Cognitive Behavior Therapy • EMDR Therapy In addition to our traditional residential treatment program, we offer a Christian substance abuse treatment center, Road Less Traveled. We also offer our GO program, designed to assist our patients transition from in-patient treatment to sober living.


Find More Drug And Alcohol Rehabilitation Information…