Drug and Alcohol Rehabilitation: Evaluation of Anti-Inflammatory Effects of Green Tea and Black Tea: A Comparative in Vitro Study.

Evaluation of anti-inflammatory effects of green tea and black tea: A comparative in vitro study.

Filed under: Drug and Alcohol Rehabilitation

J Adv Pharm Technol Res. 2012 Apr; 3(2): 136-8
Chatterjee P, Chandra S, Dey P, Bhattacharya S

The present study was conducted to evaluate and compare the anti-inflammatory effects of aqueous extracts of green tea and black tea leaves (Camellia sinensis) against the denaturation of protein in vitro. The test extracts at different concentrations were incubated with egg albumin under controlled experimental conditions and subjected to determination of absorbance to assess the anti-inflammatory property. Diclofenac sodium was used as the reference drug. The present results exhibited a concentration-dependent inhibition of protein (albumin) denaturation by both the tea extracts. From the present findings it can be concluded that both green and black tea leaves possessed a marked anti-inflammatory effect against the denaturation of protein, in vitro. Green tea was found to be more active than black tea, plausibly due to the higher flavonoid contents of green tea.
HubMed – drug


Development and evaluation of microporous osmotic tablets of diltiazem hydrochloride.

Filed under: Drug and Alcohol Rehabilitation

J Adv Pharm Technol Res. 2012 Apr; 3(2): 124-9
Bathool A, Gowda DV, Khan MS, Ahmed A, Vasudha SL, Rohitash K

Microporous osmotic tablet of diltiazem hydrochloride was developed for colon targeting. These prepared microporous osmotic pump tablet did not require laser drilling to deliver the drug to the specific site of action. The tablets were prepared by wet granulation method. The prepared tablets were coated with microporous semipermeable membrane and enteric polymer using conventional pan coating process. The incorporation of sodium lauryl sulfate (SLS), a leachable pore-forming agent, could form in situ delivery pores while coming in contact with gastrointestinal medium. The effect of formulation variables was studied by changing the amounts of sodium alginate and NaCMC in the tablet core, osmogen, and that of pore-forming agent (SLS) used in the semipermeable coating. As the amount of hydrophilic polymers increased, drug release rate prolonged. It was found that drug release was increased as the concentration of osmogen and pore-former was increased. Fourier transform infrared spectroscopy and Differential scanning calorimetry results showed that there was no interaction between drug and polymers. Scanning electron microscopic studies showed the formation of pores after predetermined time of coming in contact with dissolution medium. The formation of pores was dependent on the amount of pore former used in the semipermeable membrane. in vitro results showed acid-resistant, timed release at an almost zero order up to 24 hours. The developed osmotic tablets could be effectively used for prolonged delivery of Diltiazem HCl.
HubMed – drug


Acute, sub-chronic oral toxicity studies and evaluation of antiulcer activity of Sooktyn in experimental animals.

Filed under: Drug and Alcohol Rehabilitation

J Adv Pharm Technol Res. 2012 Apr; 3(2): 117-23
Chandra P, Sachan N, Kishore K, Ghosh AK

Sooktyn (SKN), mineralo-herbal drug which is being used largely by the patients for its extremely good therapeutic value to treat the gastric ulcers. The present study was undertaken to evaluate the toxicity studies and antiulcer activity of SKN. Acute and sub-chronic toxicities were studied in male and female Wistar rats. A single acute SKN of 2 000 mg/kg was administered by oral gavage for acute toxicity. Sub-chronic doses were 400 and 800 mg/kg/day. The major toxicological end points examined included animal body weight and food intake, selected tissue weights, and detailed gross necropsy. In addition, we examined blood elements: hematocrit, hemoglobin concentration, erythrocyte count, total leukocyte count and MCH, MCHC and platelets as well as biochemical parameters: urea, sugar, alanine transaminase, aspartate transaminase, alkaline phosphatase, total proteins, and creatinine. Also, anti-ulcer activity was carried out by employing indomethacin, ethanol, pylorus ligation, and hypothermic-stress-induced ulcer models. LD(50) may be greater than 2 000 mg/kg (orally) for SKN and there were no signs of toxicity on 28 days sub-chronic oral administration of 400 and 800 mg/kg of SKN in rats on the basis of blood elements and biochemical parameters. The ulcer indices decrease in all ulcer models with 66.62%, 61.24%, 80.18%, and 74.76% in indomethacin, ethanol, pylorus ligation, and hypothermic-stress-induced ulcer models, respectively. The results suggest that SKN has no signs of toxicity at 2 000 mg/kg body weight of rats orally; sub-chronically. The drug is safe and has antiulcer activity.
HubMed – drug



Equine Therapy at work at a Drug and Alcohol Rehab in Tucson, Arizona – www.cottonwooddetucson.com An HD video of Cottonwood de Tucson’s Equine Therapy program. Among a variety of holistic treaments, the equine therapy program at Cottonwood de Tucson, a drug and alcohol rehabilitation center in Tucson, Arizona works with each patient to help explore boundaries, intimacy issues as well as mirror behaviorial patterns. While working with the horses patients experience an awareness of their own emotional state reflected in the horses actions. The horses experience the present moment with no motives or judgments and working with them patients can process perceived fear of rejection. Horse-assisted therapy demands a level of authenticity from the patient. Working with the horses can provide a rich opportunity to discover inner demons and inner strenghts. Cottonwood de Tucson Addiction Rehab Cottonwood de Tucson


Chris Christie: Every Life Is Precious And That Includes Drug Addicts [VIDEO

Filed under: Drug and Alcohol Rehabilitation

The new law expands the number of criminal offenders eligible for treatment for drug or alcohol addiction under supervision of the State's drug court programs by removing some of the disqualifications currently in place for eligibility into those programs.
Read more on New Jersey 101.5 FM Radio


Drugs and alcohol are 'an escape from reality'

Filed under: Drug and Alcohol Rehabilitation

It was the 24th such ceremony at San Blas. Twenty-two young people graduated, getting a certificate after ending a rehabilitation programme. Mgr Grech said that according to the latest report of the European School Survey Project on Alcohol and Other …
Read more on Malta Independent Online


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