Drug and Alcohol Rehabilitation: Comparison of Aerobic Conjunctival Bacterial Flora in Pregnant, Reproductive-Aged and Postmenopausal Women.

Comparison of aerobic conjunctival bacterial flora in pregnant, reproductive-aged and postmenopausal women.

Filed under: Drug and Alcohol Rehabilitation

Int J Ophthalmol. 2012; 5(6): 731-6
Balikoglu-Yilmaz M, Sen E, Sevket O, Polat Y, Karabulut A, Uysal O

To evaluate the effect of hormonal status on aerobic conjunctival flora in women.One hundred fifty-eight women [reproductive-aged (n=55), pregnant (n=51), and postmenopausal (n=52)] who admitted to outpatient clinic of Obstetrics and Gynecology Department of Denizli State Hospital were enrolled. Age, body-mass index (BMI), obstetric history, cigarette smoking, drug usage, presence of systemic disease, and intraocular pressure (IOP) were recorded for each patient. The samples were taken from the lower fornix with two culture swabs and directly incubated in culture containing 5% sheep blood, eosin-methylene blue and chocolate agar. The other swab specimen was Gram stained. All growths and microscopic results were analyzed.The coagulase-negative Staphylococcus was the predominant organism isolated in the conjunctival samples in both three groups. The aerobic microorganism growth rate for all isolated aerobic organisms revealed no significant change in the three groups (P >0.05). The conjunctival culture positivity rates were similar in the three groups (49% in reproductive-aged, 57% in pregnant and 58% in postmenopausal women) (P >0.05). Age, IOP, BMI, gravidity, parity, cigarette smoking, drug usage, and presence of systemic diseases did not have an effect on culture positivity in three groups.Results of this study showed that conjunctival aerobic flora and bacterial colonization did not differ between reproductive-aged, pregnant and postmenopausal women.
HubMed – drug

 

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).

Filed under: Drug and Alcohol Rehabilitation

Medchemcomm. 2012 Jun 1; 3(6): 699-709
Pireddu R, Forinash KD, Sun NN, Martin MP, Sung SS, Alexander B, Zhu JY, Guida WC, Schönbrunn E, Sebti SM, Lawrence NJ

Potent ROCK inhibitors of a new class of 1-benzyl-3-(4-pyridylthiazol-2-yl)ureas have been identified. Remarkable differences in activity were observed for ureas bearing a benzylic stereogenic center. Derivatives with hydroxy, methoxy and amino groups at the meta position of the phenyl ring give rise to the most potent inhibitors (low nM). Substitutions at the para position result in substantial loss of potency. Changes at the benzylic position are tolerated resulting in significant potency in the case of methyl and methylenehydroxy groups. X-Ray crystallography was used to establish the binding mode of this class of inhibitors and provides an explanation for the observed differences of the enantiomer series. Potent inhibition of ROCK in human lung cancer cells was shown by suppression of the levels of phosphorylation of the ROCK substrate MYPT-1.
HubMed – drug

 

Development of a Nephrotic Syndrome in a Patient with Gastrointestinal Stromal Tumor during a Long-Time Treatment with Sunitinib.

Filed under: Drug and Alcohol Rehabilitation

Case Rep Oncol. 2012 Sep; 5(3): 651-6
Pallotti MC, Pantaleo MA, Nannini M, Centofanti F, Fabbrizio B, Montanari M, Baraldi O, Saponara M, Lolli C, Mandrioli A, Biasco G, Prandini R

A patient with advanced gastrointestinal stromal tumor (GIST) receiving second-line treatment with sunitinib developed edema, increase of the serum creatinine, weight gain, nephrotic syndrome with proteinuria of 12 g/24 h, dyslipidemia, hypoalbuminemia and also presented with hypertension. A kidney biopsy showed an immunocomplex glomerulonephritis. Steroid treatment was started, but the clinical conditions and laboratory values did not improve. So in the hypothesis that the nephrotic syndrome was induced by sunitinib, sunitinib was temporarily discontinued with a subsequent reduction of proteinuria and improvement in blood pressure control. In the last years, the introduction of sunitinib has modified the natural history of advanced GIST. However, due to chronic and prolonged intake of this drug, there is increasingly frequent detection of late and unknown toxicities in clinical practice. In particular, the late renal toxicity from sunitinib may be the primary clinical problem with this drug in the case of prolonged treatment. Monitoring of kidney function and blood pressure should be performed for early detection of side effects such as hypertension and kidney dysfunction in advanced GIST patients receiving long-term treatment with sunitinib. A clinical collaboration between oncologists and nephrologists could be useful with the objective to optimize the management of sunitinib.
HubMed – drug

 


 

Untreated: Volume 4 “April’s Trip” – Untreated is an original, comedy web series that explores the wild and wonderfully bizarre world of life inside the walls of a pint-sized drug and alcohol rehabilitation center. Filtered through the eyes of our colorful core of characters, we discover that sobriety and sanity do not necessarily go hand in hand. Furthermore, this mixed up bag of nuts seems to only have one thing in common: that they are all completely unready, totally unwilling and entirely Untreated! Contact Demian Slade & Quincy Rose at: UntreatedTheSeries@gmail.com Credits: Executive Produced, Created & Written by: Demian Slade Produced, Edited & Directed by: Quincy Rose Director of Photography: Matt Fore Starring: Demian Slade as Joe Zach Tiegen as Doug Jenn Gulotta as April Elizabeth Hendrix as Shorty Brown Albert Malafronte as Dr. Stan Quincy Rose as Rich Gregor Manns as Freddy Maja Miletich as Barbie Co-Executive Producer: Susan Martinson Assistant Director & Assistant Camera: Alex Rinks Sound Mixer & Boom Operator: Benny Adams Special Thanks: Betsy Phillips “Untreated” and all volumes and clips related are the sole property of Demian Slade & Quincy Rose. copyright 2011 & 2012 Demian Slade & Quincy Rose: UntreatedTheSeries@gmail.com

 

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