Drug and Alcohol Rehabilitation: Bath Salts: They Are Not What You Think.

Bath salts: they are not what you think.

Filed under: Drug and Alcohol Rehabilitation

J Psychosoc Nurs Ment Health Serv. 2012 Feb; 50(2): 17-21
Wieland DM, Halter MJ, Levine C

Psychoactive bath salts are a relatively new group of designer drugs sold as tablets, capsules, or powder and pur-chased in places such as tobacco and convenience stores, gas stations, head shops, and the Internet. Bath salts are stimulant agents that mimic cocaine,lysergic acid diethylamide, methamphetamine, or methylenedioxymethamphetamine (ecstasy). The most common bath salts are the cathinone derivatives 3,4-methylenedioxypyrovalerone(MDPV), 4-methylmethcathinone(mephedrone), and 3,4-methylenedioxy-N-methylcathinone (methylone). The drugs cause intense stimulation, eu-phoria, elevated mood, and a pleasurable “rush” Tachycardia, hypertension,peripheral constriction, chest pain, hallucinations, paranoia, erratic behavior,inattention, lack of memory of substance use, and psychosis have been observed in those who have used bath salts. The U.S. Drug Enforcement Administration recently exercised an emergency authority to name three key ingredients in bath salts as Schedule I, thereby making them illegal to possess or sell in the United States. Nursing implications related to both clinical and educational settings are discussed.
HubMed – drug


Graphene oxide integrated sensor for electrochemical monitoring of mitomycin C-DNA interaction.

Filed under: Drug and Alcohol Rehabilitation

Analyst. 2012 Mar 22;
Erdem A, Muti M, Papakonstantinou P, Canavar E, Karadeniz H, Congur G, Sharma S

We present a graphene oxide (GO) integrated disposable electrochemical sensor for the enhanced detection of nucleic acids and the sensitive monitoring of the surface-confined interactions between the anticancer drug mitomycin C (MC) and DNA. Interfacial interactions between immobilized calf thymus double-stranded (dsDNA) and anticancer drug MC were investigated using differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) techniques. Based on three repetitive voltammetric measurements of 120 ?g mL(-1) DNA immobilized on GO-modified electrodes, the RSD % (n = 3) was calculated as 10.47% and the detection limit (DL) for dsDNA was found to be 9.06 ?g mL(-1). EIS studies revealed that the binding of the drug MC to dsDNA leads to a gradual decrease of its negative charge. As a consequence of this interaction, the negative redox species were allowed to approach the electrode, and thus increase the charge transfer kinetics. On the other hand, DPV studies exploited the decrease of the guanine signal due to drug binding as the basis for specifically probing the biointeraction process between MC and dsDNA.
HubMed – drug


Inhibition of ER? Induces Resistance to Cisplatin by Enhancing Rad51-Mediated DNA Repair in Human Medulloblastoma Cell Lines.

Filed under: Drug and Alcohol Rehabilitation

PLoS One. 2012; 7(3): e33867
Wilk A, Waligorska A, Waligorski P, Ochoa A, Reiss K

Cisplatin is one of the most widely used and effective anticancer drugs against solid tumors including cerebellar tumor of the childhood, Medulloblastoma. However, cancer cells often develop resistance to cisplatin, which limits therapeutic effectiveness of this otherwise effective genotoxic drug. In this study, we demonstrate that human medulloblastoma cell lines develop acute resistance to cisplatin in the presence of estrogen receptor (ER) antagonist, ICI182,780. This unexpected finding involves a switch from the G2/M to G1 checkpoint accompanied by decrease in ATM/Chk2 and increase in ATR/Chk1 phosphorylation. We have previously reported that ER?, which is highly expressed in medulloblastomas, translocates insulin receptor substrate 1 (IRS-1) to the nucleus, and that nuclear IRS-1 binds to Rad51 and attenuates homologous recombination directed DNA repair (HRR). Here, we demonstrate that in the presence of ICI182,780, cisplatin-treated medulloblastoma cells show recruitment of Rad51 to the sites of damaged DNA and increase in HRR activity. This enhanced DNA repair during the S phase preserved also clonogenic potential of medulloblastoma cells treated with cisplatin. In conclusion, inhibition of ER? considered as a supplemental anticancer therapy, has been found to interfere with cisplatin-induced cytotoxicity in human medulloblastoma cell lines.
HubMed – drug


Prediction of promiscuous p-glycoprotein inhibition using a novel machine learning scheme.

Filed under: Drug and Alcohol Rehabilitation

PLoS One. 2012; 7(3): e33829
Leong MK, Chen HB, Shih YH

P-glycoprotein (P-gp) is an ATP-dependent membrane transporter that plays a pivotal role in eliminating xenobiotics by active extrusion of xenobiotics from the cell. Multidrug resistance (MDR) is highly associated with the over-expression of P-gp by cells, resulting in increased efflux of chemotherapeutical agents and reduction of intracellular drug accumulation. It is of clinical importance to develop a P-gp inhibition predictive model in the process of drug discovery and development.An in silico model was derived to predict the inhibition of P-gp using the newly invented pharmacophore ensemble/support vector machine (PhE/SVM) scheme based on the data compiled from the literature. The predictions by the PhE/SVM model were found to be in good agreement with the observed values for those structurally diverse molecules in the training set (n?=?31, r(2)?=?0.89, q(2)?=?0.86, RMSE?=?0.40, s?=?0.28), the test set (n?=?88, r(2)?=?0.87, RMSE?=?0.39, s?=?0.25) and the outlier set (n?=?11, r(2)?=?0.96, RMSE?=?0.10, s?=?0.05). The generated PhE/SVM model also showed high accuracy when subjected to those validation criteria generally adopted to gauge the predictivity of a theoretical model.This accurate, fast and robust PhE/SVM model that can take into account the promiscuous nature of P-gp can be applied to predict the P-gp inhibition of structurally diverse compounds that otherwise cannot be done by any other methods in a high-throughput fashion to facilitate drug discovery and development by designing drug candidates with better metabolism profile.
HubMed – drug



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The Situation seeking rehab for alcohol, drugs: report

Filed under: Drug and Alcohol Rehabilitation

According to TMZ, the large amount of alcohol the reality star regularly imbibed on the show was partially responsible for his recent rehab stint. More than that, however, former castmate Angelina Pivarnick claims Sorrentino was also doing drugs.
Read more on New York Daily News


Atiyeh Proposes More Drug Treatment Centers

Filed under: Drug and Alcohol Rehabilitation

Developer Abraham Atiyeh has submitted plans to convert the recently closed Moose & Bug flower shop, 2349 Linden St., to a rehabilitation center for drug and alcohol treatment. With a rejection of his plans to put an inpatient drug and alcohol …
Read more on Patch.com


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