Development of a Chewable Tablet From Dugdh?Malaky?Di Yoga: An Ayurvedic Preparation.

Development of a chewable tablet from Dugdh?malaky?di Yoga: An Ayurvedic preparation.

Anc Sci Life. 2012 Jul; 32(1): 34-7
Santhosh SB, Ambi AB, Hiremath RR, Mannur VS

?malaki (Embelica officinalis Gaertn.) is one of the most celebrated herbs in the Indian system of traditional medicine. It is one of the best Ras?yana-s (health promoting) drug. In Dugdh?malaky?di yoga, ?malaki (Embelica officinalis Gaertn.) powder is administered along with milk in case of svarabha?ga (hoarseness of voice). Here an attempt is made to convert this formulation into chewable tablet without altering its property to improve its palatability, shelf life and fixation of proper therapeutic dose.Chewable tablets were prepared by wet granulation method. Here, ?malaki powder was prepared initially and it was mixed with additives and preservatives. Granules were prepared from this mixture by adding binding agent, finally compressed in to tablets.The physico-chemical analysis of ?malaki standard are: Foreign Matter-Nil, Acid insoluble Ash-0.51%w/w, Water soluble Ash-2.01% w/w, Alcoholic Extractives-44.48%, Aqueous Extractives 67.52%, pH-3.1, Moisture content-8.19%. Quality control test for chewable tablet was carried out and found satisfactory with general characteristics of tablet viz. hardness 1.8, disintegration time 15-20 min, friability 0.5%, weight variation +/- 3%. The TLC of ?malaki powder showed 3 spots with Rf value 0.14, 0.4, and 0.73 and the chewable tablets showed 2 spots with Rf value 0.31 and 0.89 under 254 nm. The adaptation of modern techniques or methods to convert the Ayurvedic formulations without altering its therapeutic property is necessary to made them suitable for the present trends of newer drug delivery dosage forms. HubMed – drug

Microscopic characterization of Scoparia dulcis Linn.(Scrophulariaceae).

Anc Sci Life. 2012 Jul; 32(1): 29-33
Mishra MR, Mishra A, Pradhan DK, Behera RK, Jha S, Panda AK, Choudhary PR

This manuscript covers a detailed pharmacognostic evaluation of Scoparia dulcis Linn. whole plant (Scrophulariaceae), including morphology, microscopy, physicochemical, and phytochemical screening. Microscopy of different plant part was done by performing transverse sections and longitudinal sections, which were identified by the different staining reagents and dyes. Physicochemical constants were done for whole plant; it includes ash value, extractive value and moisture content. Phytochemical screening was done for aqueous and methanolic extract in maceration and soxhletion, results revealed the presence of alkaloids, glycosides, carbohydrates, phenolic compound, flavonoids, saponins, proteins, and amino acids. These study includes parameters to establish the authenticity of S. dulcis and can possibly help to differentiate the drug from its other species. HubMed – drug

Evaluation of in vitro antioxidant capacity and reducing potential of polyherbal drug- Bh?ra?gy?di.

Anc Sci Life. 2012 Jul; 32(1): 24-8
Kajaria DK, Gangwar M, Sharma AK, Tripathi YB, Tripathi JS, Tiwari S

Present work was designed to investigate antioxidant activity of polyherbal formulation in search for new, safe and inexpensive antioxidant. Clerodendrum serratum, Hedychium spicatum and Inula racemosa, were extensively used in ayurvedic medicine and were investigated together in the form of polyherbal compound (Bh?ra?gy?di) for their antioxidant potential.Hydroalcoholic extract was prepared from the above samples and was tested for total reducing power and in vitro antioxidant activity by ABTS(+) assay, Superoxide anion scavenging activity assay and lipid per-oxidation assay.Reducing power shows dose depended increase in concentration maximum absorption of 0.677 ± 0.017 at 1000 ?g/ml compared with standard Quercetin 0.856±0.020. ABTS(+) assay shows maximum inhibition of 64.2 ± 0.86 with EC50 675.31 ± 4.24. Superoxide free radical shows maximum scavenging activity of 62.45 ± 1.86 with EC50 774.70 ± 5.45. Anti-lipidperoxidation free radicals scavenge maximum absorption of 67.25± 1.89 with EC50 is 700.08 ± 6.81. Ascorbic acid was used as standard with IC50 value is 4.6 ?g/ml. The result suggests polyherbal formulation to be a good potential for antioxidant activity. Oxidative stress results from imbalance between free radical-generation and radical scavenging systems. This will lead to tissue damage and oxidative stress.In conclusion, we strongly suggest that Polyherbal compounds are source of potential antioxidant for radical scavenging. The highly positive correlation of antiradical scavenging activity and total polyphenolic content in Polyherbal compounds indicates that polyphenols are important components which could be used for the free radical scavenging activity. Further study is needed for isolation and characterization of the active moiety responsible for biological activity and to treat in various stress condition. HubMed – drug