Depression Treatment: The Influence of the Tricyclic Antidepressant Amitriptyline on Periodic Limb Movements During Sleep.

The Influence of the Tricyclic Antidepressant Amitriptyline on Periodic Limb Movements during Sleep.

Filed under: Depression Treatment

Pharmacopsychiatry. 2013 Jan 4;
Goerke M, Rodenbeck A, Cohrs S, Kunz D

Many antidepressants are associated with periodic limb movements (PLM) during sleep. Although some tricyclic antidepressants, such as amitriptyline, promote sleep and are thus often prescribed as a treatment for sleep disturbances that can accompany depression, it remains unclear whether amitriptyline is associated with PLM.32 healthy males (18-39 years) spent 2 consecutive nights in the sleep lab for polysomnographic recording. During the second night, they received either 75?mg amitriptyline or placebo in a randomized, double-blind, placebo-controlled manner.In subjects receiving amitriptyline but not in subjects receiving placebo, the number of periodic leg movements per h was significantly increased from baseline to intervention night. However, objective polysomnographic sleep parameters (such as the number of awakenings, wake after sleep onset, and sleep efficiency) and subjective sleep perception were not significantly associated with any PLM indices.Our findings indicate that amitriptyline can induce or even increase the number of PLM during sleep in healthy subjects. When treating sleep disturbances with amitriptyline, PLM should be considered as a possible cause of insufficient improvement.
HubMed – depression


Intentional Growth Training: Developing an Intervention to Increase Personal Growth Initiative.

Filed under: Depression Treatment

Appl Psychol Health Well Being. 2013 Jan 4;
Thoen MA, Robitschek C

Background: A one-week intervention (Intentional Growth Training; IGT) to increase personal growth initiative (PGI) was created and tested in a series of studies to determine its effect on PGI level. Because PGI predicts psychological well-being and depression, IGT has potential to have considerable benefit on a person’s mental health. Methods: Study 1 was the initial assessment of whether IGT increased PGI greater than various control conditions. Study 2 employed an enhanced version of IGT and utilised the singular components of IGT determining which components were most impactful at increasing PGI. Study 3 was a narrative analysis of writing samples from Study 2 determining whether participant language varied by condition in use of negative or positive emotion, or personal growth-related words. Results: In Study 1, PGI increased significantly across conditions. In Study 2, the growth activity only condition, and PGI education coupled with the growth activity, produced significant increases in PGI. In Study 3, those receiving only PGI education used more growth-related words than control conditions. Conclusion: The most effective IGT format appears to include both education about PGI and a growth activity. The benefits of utilising IGT are discussed.
HubMed – depression



Filed under: Depression Treatment

Am J Epidemiol. 2013 Jan 4;
Vanderweele TJ

HubMed – depression


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