Depression Treatment: [The Comparative Study on the Efficacy of the Combination of Serotonin Reuptake Inhibitor Antidepressants and Antipsychotics in the Treatment of Recurrent Depressive Disorders.]

[The comparative study on the efficacy of the combination of serotonin reuptake inhibitor antidepressants and antipsychotics in the treatment of recurrent depressive disorders.]

Filed under: Depression Treatment

Zh Nevrol Psikhiatr Im S S Korsakova. 2012; 112(11 Vypusk 2 Depressija): 61-66
D’iakonov AL, Lobanova IV

A combination of serotonin reuptake inhibitor antidepressants (prozac and stimulaton) with atypical antipsychotics (zyprexa and solian) reduced depression in patients with recurrent depressive disorders during 10 days. The effect was evenly distributed between 10, 20 and 40 days of treatment. Other symptoms had a peculiar dynamics depending on the therapy. By the end of the study, similar effects were achieved for all groups. The addition of antipsychotics to antidepressant treatment insignificantly increased the number of adverse events.
HubMed – depression

 

[A comparative evaluation of the efficacy of valdoxan (agomelatine) in recurrent depression and bipolar affective disorder.]

Filed under: Depression Treatment

Zh Nevrol Psikhiatr Im S S Korsakova. 2012; 112(11 Vypusk 2 Depressija): 53-60
Tiuvina NA, Smirnova VN

Authors compared the efficacy and safety of valdoxan in the treatment of depression in 22 patients with recurrent depressive disorder (RD) and 23 patients with bipolar affective disorder (BAD). Valdoxan was used on the night in dosage 25-50 mg during 8 weeks. Efficacy was assessed with psychometric scales HAM-D-17, CGI-S, CGI-I and visual analogous scales for falling asleep, night sleep quality, morning status and day activity. The antidepressant effect of the drug and the normalization of circadian rhythms were seen in the first week of treatment. To the end of treatment, there were 90.9% responders in the group with BAD and 91.3% in patients with RD. Percentages of patients with remission were 65.2% and 54.5%, respectively. It has been concluded that valdoxan does not cause unwanted side-effects as well as the risk of the inversion of a phase and/or the development of transitory hypomania in BAD.
HubMed – depression

 

[The dynamics of anxious depression under the treatment with antidepressants with different mechanisms of action.]

Filed under: Depression Treatment

Zh Nevrol Psikhiatr Im S S Korsakova. 2012; 112(11 Vypusk 2 Depressija): 41-47
Maksimova NM, Vertogradova OP

Peculiarities of the dynamics of anxious depression under the treatment with selective serotonergic antidepressants with different mechanisms of action on the serotonin reuptake were investigated. It was examined 61 patients with anxious depression (ICD-10 F32.1, F33.1, F34.1) treated with zoloft (sertraline) or coaxil (tianeptine) as a monotherapy. The following methods were used: clinical-psychopathological, psychometric (Hamilton Rating Scales for Depression and Anxiety, the Sheehan Patient-Related Anxiety Scale) and statistical analysis. The comparative investigation has shown that both zoloft and coaxil are practically equally effective in the treatment of anxious depression with some peculiarities in the dynamics of clinical parameters.
HubMed – depression

 

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