Depression Treatment: Increased Risk of Major Depression by Childhood Abuse Is Not Modified by CNR1 Genotype.

Increased risk of major depression by childhood abuse is not modified by CNR1 genotype.

Filed under: Depression Treatment

Am J Med Genet B Neuropsychiatr Genet. 2012 Dec 19;
Pearson JF, Fergusson DM, Horwood LJ, Miller AL, Sullivan PF, Youfang LE, Kennedy MA

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A pulmonary exacerbation risk score among cystic fibrosis patients not receiving recommended care.

Filed under: Depression Treatment

Pediatr Pulmonol. 2012 Dec 19;
Sawicki GS, Ayyagari R, Zhang J, Signorovitch JE, Fan L, Swallow E, Latremouille-Viau D, Wu EQ, Shi L

BACKGROUND: Pulmonary exacerbations (PEx) lead to substantial morbidity in cystic fibrosis (CF), and guidelines recommend chronic medication including dornase alfa and inhaled tobramycin. However PEx risk and medication use vary across patients. OBJECTIVE: To develop a PEx risk score among CF patients not receiving guideline-recommended chronic respiratory medications. METHODS: A cohort of patients with FEV1%-predicted between 25% and 75% without evidence of dornase alfa or inhaled tobramycin use in an index year, despite meeting guideline recommended criteria, was identified from the CF Foundation Patient Registry (2002-2008). This sample was randomly split into 2/3 for a development sample and 1/3 for a validation sample. A multivariable risk score was developed to predict PEx requiring hospitalization or home IV treatment using available patient characteristics. Its predictive performance was assessed in the validation sample. RESULTS: Among 3,069 patient-years, 1,275 (42%) had PEx in the subsequent year. The risk score included, in order of decreasing impact on PEx risk, prior PEx, Pseudomonas aeruginosa, allergic bronchopulmonary aspergillosis, depression, methicillin-resistant Staphylococcus aureus, CF-related diabetes, Burkholderia cepacia, prior use of dornase alfa, bronchodilator use, prior use of inhaled tobramycin and lower FEV1%-predicted. Stratifying patients by risk score in the validation sample identified actual risks ranging from 14% in the lowest decile to 90% in the highest. The c-statistic was 0.8. CONCLUSIONS: A PEx risk score for CF patients not receiving guideline-recommended chronic therapies was developed and validated, and identified patients with a wide range of risk. This score could identify high-risk patients in whom chronic therapies should be initiated or continued. Pediatr Pulmonol. © 2012 Wiley Periodicals, Inc.
HubMed – depression


Short forms of the Postpartum Depression Screening Scale: as accurate as the original form.

Filed under: Depression Treatment

Arch Womens Ment Health. 2012 Dec 20;
Pereira AT, Bos S, Marques M, Maia B, Soares MJ, Valente J, Nogueira V, de Azevedo MH, Macedo A

The aims of the present study were to develop three shorter forms of the Portuguese version of the Postpartum Depression Screening Scale (PDSS) as adapted and translated in Portugal, to analyse their psychometrics and to determine their cut-off points and associated conditional probabilities to screen for perinatal depression according to DSM-IV and ICD-10 criteria. In this study, 441 women in the third trimester of pregnancy and 453 in the third month of postpartum were interviewed for diagnostic purposes according to the Portuguese versions of the Diagnostic Interview for Genetic Studies and the Operational Criteria Checklist for Psychotic Illness. DSM-IV and ICD-10 classifications of depression were our gold standards for caseness. Three different shorter forms of the original Portuguese version of the PDSS were developed on the basis of reliability and factorial analysis. PDSS short versions, composed of seven and 21 (postpartum)/24 (pregnancy) items, presented significant reliability and validity and showed satisfactory combinations of sensitivity and specificity (?80 %). The short forms of the original Portuguese version of the PDSS are valid alternatives to the 35-item version, given their equally precise screening performances, more concise structures and ease of completion.
HubMed – depression


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