Depression Treatment: Fear of Falling and Balance Ability in Older Men: The Priest Study.

Fear of Falling and Balance Ability in Older Men: The Priest Study.

Filed under: Depression Treatment

J Aging Phys Act. 2012 Nov 19;
Klima DW, Newton RA, Keshner EA, Davey A

Studies examining fear of falling among older adult men remain limited. The objectives of this study were to compare balance confidence in two age cohorts of older clergy and identify predictive determinants of balance confidence in a liturgical research initiative. Participants included 131 community-dwelling Roman Catholic priests aged 60-97 years living in religious communities in 10 Mid-Atlantic states. Subjects completed the Activities-specific Balance Confidence Scale (ABC), Berg Balance Scale (BBS), Timed Up and Go (TUG) Test, and 15-item Geriatric Depression Scale (GDS). Younger priests (60-74 years) demonstrated a significantly higher ABC score than the older cohort (75 and above years) of priests (89.1± 12.6 vs.78.4 ± 13.9, p =0.001). Confidence was significantly correlated with BBS (rho=0.69; p<0.01), TUG (r= -0.58; p<0.01), and GDS (r=-0.39; p<0.01) scores. A stepwise regression model demonstrated that balance ability, mood, assistive device use, and physical activity predicted 52% of the variance in balance confidence. HubMed – depression


[Dysthimia or chronic depression: what do we know about its pharmacological treatment?].

Filed under: Depression Treatment

Vertex. 2012 Jul-Aug; 23(104): 260-4
Wikinski S

The term dysthymia is applied to a clinical picture characterized by depressive feelings of low intensity and chronic evolution. Psychiatric nosology includes it among the mood disorders or among neurosis and personality disorders. This ambiguity has empirical consequences, since bibliography examining the efficacy of the different treatments is relatively scarce, in particular if we consider the incidence of the dysthymic disorder, that rounds 3% of general population. In this work the history of the nosology of dysthimia, the efficacy of pharmacological approaches and a brief mention about the efficacy of adding psychotherapy are summarized. Current literature indicates that antidepressants, independently of the group they form part of, are better than placebo, that maintenance treatment should be recommended and that psychotherapy could bring an additional benefit.
HubMed – depression


Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism.

Filed under: Depression Treatment

Exp Ther Med. 2012 Oct; 4(4): 627-632
Zhong JM, Wu SY, Bai J, Guo Q, Tao J, Chen H, Zhao NW, Zhao Z, Fu H

Depression is a highly debilitating and widely distributed illness in the general population. Geranylgeranylacetone (GGA), a non-toxic anti-ulcer drug, has been reported to have protective effects in the central nervous system. The aim of this study was to determine the antidepressant effect of GGA in a chronic mild stress (CMS) model of depression. We confirmed that CMS in rats caused a reduction in locomotor activity and an increase in the levels of monoamine oxidase-A (MAO-A) and caspase-3 in the hippocampus. GGA treatment reversed stress-induced alterations in locomotor activity and target levels of MAO-A and caspase-3. In addition, GGA treatment induced heat shock protein 70 (Hsp70) expression in the hippocampus. These findings suggest that GGA possesses an antidepressant activity in a CMS model of depression. The activity of GGA in the relief of depression may be mediated via the induction of Hsp70 expression to suppress MAO-A expression and the apoptosis cascade.
HubMed – depression


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