Depression Treatment: Corrigendum: Serotonin Transporter Gene, Stress, and Raphe–Raphe Interactions: A Molecular Mechanism of Depression.

Corrigendum: Serotonin transporter gene, stress, and raphe–raphe interactions: a molecular mechanism of depression.

Filed under: Depression Treatment

Trends Neurosci. 2012 Jul; 35(7): 454-5
Jasinska AJ, Lowry CA, Burmeister M

HubMed – depression


Does depression impact cognitive impairment in patients with heart failure?

Filed under: Depression Treatment

Cardiol Res Pract. 2012; 2012: 524325
Sohani ZN, Samaan Z

Prevalence studies have noted the cooccurrence of cognitive decline and depression in persons with heart failure. Cognitive impairment is associated with significant mortality and deteriorated quality of life, likely due to impairments in memory and executive function, which impact a patient’s ability to understand and comply with prescribed treatment plans. This is especially true in complex diseases such as heart failure. Evidence from literature supports the possibility of a pathophysiological relationship between cognitive impairment, depression, and heart failure. Yet, very few studies have sought to investigate this relationship. This paper reviews current literature on the association between depression and cognitive impairment in persons with heart failure and explores possible mechanisms explaining this complex triad.
HubMed – depression


ALS and Frontotemporal Dysfunction: A Review.

Filed under: Depression Treatment

Neurol Res Int. 2012; 2012: 806306
Achi EY, Rudnicki SA

Though once believed to be a disease that was limited to the motor system, it is now apparent that amyotrophic lateral sclerosis (ALS) may be associated with cognitive changes in some patients. Changes are consistent with frontotemporal dysfunction, and may range from mild abnormalities only recognized with formal neuropsychological testing, to profound frontotemporal dementia (FTD). Executive function, behavior, and language are the most likely areas to be involved. Screening helpful in detecting abnormalities includes verbal or categorical fluency, behavioral inventories filled out by the caregiver, and evaluation for the presence of depression and pseudobulbar affect. Patients with cognitive dysfunction have shortened survival and may be less compliant with recommendations regarding use of feeding tubes and noninvasive ventilation. Evolving knowledge of genetic and pathological links between ALS and FTD has allowed us to better understand the overlapping spectrum of ALS and FTD.
HubMed – depression



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