Depression Treatment: An Instant Diagnosis for Depression by Blood Test.

An instant diagnosis for depression by blood test.

Filed under: Depression Treatment

J Clin Diagn Res. 2012 Nov; 6(9): 1612-3
Verma RK, Kaur S, David SR

HubMed – depression


The effectiveness of an online support group for members of the community with depression: a randomised controlled trial.

Filed under: Depression Treatment

PLoS One. 2012; 7(12): e53244
Griffiths KM, Mackinnon AJ, Crisp DA, Christensen H, Bennett K, Farrer L

Internet support groups (ISGs) are popular, particularly among people with depression, but there is little high quality evidence concerning their effectiveness.The study aimed to evaluate the efficacy of an ISG for reducing depressive symptoms among community members when used alone and in combination with an automated Internet-based psychotherapy training program.Volunteers with elevated psychological distress were identified using a community-based screening postal survey. Participants were randomised to one of four 12-week conditions: depression Internet Support Group (ISG), automated depression Internet Training Program (ITP), combination of the two (ITP+ISG), or a control website with delayed access to e-couch at 6 months. Assessments were conducted at baseline, post-intervention, 6 and 12 months.There was no change in depressive symptoms relative to control after 3 months of exposure to the ISG. However, both the ISG alone and the combined ISG+ITP group showed significantly greater reduction in depressive symptoms at 6 and 12 months follow-up than the control group. The ITP program was effective relative to control at post-intervention but not at 6 months.ISGs for depression are promising and warrant further empirical ISRCTN65657330.
HubMed – depression


Age-Related Changes in the Global DNA Methylation Profile of Leukocytes Are Linked to Nutrition but Are Not Associated with the MTHFR C677T Genotype or to Functional Capacities.

Filed under: Depression Treatment

PLoS One. 2012; 7(12): e52570
Gomes MV, Toffoli LV, Arruda DW, Soldera LM, Pelosi GG, Neves-Souza RD, Freitas ER, Castro DT, Marquez AS

Global DNA methylation of peripheral blood leukocytes has been recently proposed as a potential biomarker for disease risk. However, the amplitude of the changes in DNA methylation associated with normal aging and the impacts of environmental changes on this variation are still unclear. In this context, we evaluated the association of global DNA methylation with nutritional habits, tobacco smoking, body mass index (BMI), clinical laboratory parameters, polymorphism C677T MTHFR, functional cognition and the daily practice of physical activity in a cancer-free older population. Leukocyte global DNA methylation from 126 older individuals was quantified using a high-throughput ELISA-based method. Global DNA hypomethylation was observed in older individuals when compared to a younger population (p?=?0.0469), confirming changes in DNA methylation in the aging process. Furthermore, the methylation profile of elders was correlated with the daily ingestion of carbohydrates (p?=?0.0494), lipids (p?=?0.0494), vitamin B6 (p?=?0.0421), magnesium (p?=?0.0302), and also to the serum levels of total protein (p?=?0.0004), alpha 2 globulin (p?=?0.0013) and albumin (p?=?0.0015). No statistically significant difference was observed when global DNA methylation were stratified according to C677T MTHFR genotypes (p?=?0.7200), BMI (p?=?0.1170), smoking habit (p?=?0.4382), physical activity in daily life (p?=?0.8492), scored cognitive function (p?=?0.7229) or depression state (p?=?0.8301). Our data indicate that age-related variations in the global DNA methylation profile of leukocytes might be modulated by the daily intake of carbohydrates, lipids, vitamin B6, and magnesium and be associated with serum protein levels, however it is independent of C677T MTHFR genotype and not correlated with BMI, smoking habit, cognitive function or the routine physical activities.
HubMed – depression


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