Depression Medication?

Question by sjteann: Depression medication?
Has anyone taken Pristiq for depression and could tell me their experiences with it. Thank you.

Best answer:

Answer by Dochallcom, PhD
Pristiq (desvenlafaxine) was approved by the FDA in February of 2008 for the treatment of major depressive disorder in adults. Pristiq is one of the newer serotonin and norepinephrine reuptake inhibitors (SNRIs) used in the treatment of depression. It works by increasing the amounts of serotonin and norepinephrine- natural substances in the brain- that help maintain mental balance and stop the movement of pain signals in the brain. Its effects on pain reduction, general anxiety, nerve damage, and fibromyalgia are well documented along with its usefulness as an antidepressant.

The most common side effect of SNRIs is weight loss. Clinical studies have shown that up to 9 percent of people taking an SNRI reported a loss of appetite, and weight loss. It is possible for people to lose large amounts of weight while taking the medication.

Serotonin-norepinephrine reuptake inhibitors, which include Effexor, Cymbalta, and Pristiq, have the lowest risk of sexual side-effects than most other antidepressants.

One SNRI may work better for you than another. For example, Effexor may be a good choice if you have depression that has not improved with other medications (treatment-resistant depression). Cymbalta may help ease chronic pain in addition to treating depression.

Although most people do not complain about weight loss when taking an SNRI, they do complain when the weight begins piling on once they stop taking the drug.

According to, “after you stop taking an SNRI, you may experience changes in your weight once you regain your appetite. An improved appetite associated with improved mood may result in increased weight after taking an antidepressant. Adopt healthy eating habits and engage in regular exercise to keep extra pounds at bay and lose additional weight after taking Pristiq.”

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