Cortical-Striatal Gene Expression in Neonatal Hippocampal Lesion-Amplified Cocaine Sensitization.

Cortical-striatal gene expression in neonatal hippocampal lesion-amplified cocaine sensitization.

Genes Brain Behav. 2013 May 17;
Chambers RA, McClintick JN, Sentir AM, Berg SA, Runyan M, Choi KH, Edenberg HJ

Cortical-striatal circuit dysfunction in mental illness may enhance addiction vulnerability. Neonatal ventral hippocampal lesions (NVHL) model this dual diagnosis causality by producing a schizophrenia syndrome with enhanced responsiveness to addictive drugs. Rat genome-wide microarrays containing >24,000 probsets were used to examine separate and co-occurring effects of NVHLs and cocaine sensitization (15?mg/kg/day x 5?days) on gene expression within medial prefrontal cortex (MPFC), nucleus accumbens (NAC), and caudate-putamen (CAPU). Two weeks after NVHLs robustly amplified cocaine behavioral sensitization, brains were harvested for genes of interest defined as those altered at p?HubMed – addiction



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