[Consumption of Licit and Illicit Substances by Police Officers in the City of Rio De Janeiro].

[Consumption of licit and illicit substances by police officers in the city of Rio de Janeiro].

Cien Saude Colet. 2013 Mar; 18(3): 667-76
Souza ER, Schenker M, Constantino P, Correia BS

The consumption of psychoactive substances by civil and military police of the city of Rio de Janeiro was investigated. Data was gathered from two cross-sectional studies on a questionnaire on work and health conditions given to a sample from the two corporations. The results show higher frequencies of regular consumption of tobacco (23.3% by civil police and 19.1% by military police), daily use of alcohol (12% by civil police and 11% by military police) and tranquilizers in the past year (13.3% by civil police and 10.1% by military police). The consumption of marijuana among officers was 0.1% by civil police and 1.1% by military police, and cocaine use among the military police was 1.1%. Alcohol consumption proved to be intense and causes problems at work and in the social and family relationships of these officers. The need for preventive policies for addiction and the possible underestimation of information on illicit substances is emphasized. HubMed – addiction


Influence of CYP2D6 and CYP2C19 gene variants on antidepressant response in obsessive-compulsive disorder.

Pharmacogenomics J. 2013 Apr 2;
Brandl EJ, Tiwari AK, Zhou X, Deluce J, Kennedy JL, Müller DJ, Richter MA

Numerous studies have reported on pharmacogenetics of antidepressant response in depression. In contrast, little is known of response predictors in obsessive-compulsive disorder (OCD), a disorder with among the lowest proportion of responders to medication (40-60%). Our study is the largest investigation to date (N=184) of treatment response and side effects to antidepressants in OCD based on metabolizer status for CYP2D6 and CYP2C19. We observed significantly more failed medication trials in CYP2D6 non-extensive compared with extensive metabolizers (P=0.007). CYP2D6 metabolizer status was associated with side effects to venlafaxine (P=0.022). There were nonsignificant trends for association of CYP2D6 metabolizer status with response to fluoxetine (P=0.056) and of CYP2C19 metabolizer status with response to sertraline (P=0.064). Our study is the first to indicate that CYP genes may have a role in antidepressant response in OCD. More research is required for a future clinical application of genetic testing, which could lead to improved treatment outcomes.The Pharmacogenomics Journal advance online publication, 2 April 2013; doi:10.1038/tpj.2013.12. HubMed – addiction


When addiction co-occurs with traumatic brain injury.

Am J Psychiatry. 2013 Apr 1; 170(4): 351-4
Corrigan JD, Adams RS, Larson MJ

HubMed – addiction



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