Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report.

Clonazepam as agonist substitution treatment for benzodiazepine dependence: a case report.

Filed under: Addiction Rehab

Case Rep Psychiatry. 2013; 2013: 367594
Maremmani AG, Rovai L, Rugani F, Bacciardi S, Pacini M, Dell’osso L, Maremmani I

Nowadays, the misuse of benzodiazepines (BZDs) is a cause for a serious concern among pharmacologically inexperienced patients, whether treated or untreated, that could lead to significant complications, including tolerance, dependence, and addiction. We present a case report in which an Italian patient affected by anxiety disorder and treated with BZDs presented a severe case of dependence on BZDs. We treated him according to an agonist substitution approach, switching from the abused BZD to a slow-onset, long-acting, high potency agonist (clonazepam), and looking at the methadone treatment model as paradigm. We decided to use clonazepam for its pharmacokinetic properties. The advantage of choosing a slow-onset, long-lasting BZD for the treatment of our patient was that it led us to a remarkable improvement in the clinical situation, including the cessation of craving, absence of withdrawal symptoms, reduced anxiety, improvements in social functioning, and a better cognition level.
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Reply to Dr Rolland et al re: “Baclofen for Alcohol-Dependence: Anti-Craving or Partial Substitution?”

Filed under: Addiction Rehab

J Clin Psychopharmacol. 2013 Feb 14;
Pastor A, Lloyd-Jones M, Currie J

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Baclofen for Alcohol-Dependence Anticraving or Partial Substitution?

Filed under: Addiction Rehab

J Clin Psychopharmacol. 2013 Feb 14;
Rolland B, Bordet R, Deheul S, Cottencin O

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Examining Levels of Antipsychotic Adherence to Better Understand Nonadherence.

Filed under: Addiction Rehab

J Clin Psychopharmacol. 2013 Feb 14;
Remington G, Teo C, Mann S, Hahn M, Foussias G, Agid O

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