Child and Adolescent Behavior Inventory (CABI): A New Instrument for Epidemiological Studies and Pre-Clinical Evaluation.

Child and Adolescent Behavior Inventory (CABI): A New Instrument for Epidemiological Studies and Pre-Clinical Evaluation.

Clin Pract Epidemiol Ment Health. 2013; 9: 51-61
Cianchetti C, Pittau A, Carta V, Campus G, Littarru R, Ledda MG, Zuddas A, Fancello GS

Some questionnaires have already been elaborated to collect information from parents of children and adolescents, both as preparation for clinical evaluation and for screening and epidemiological studies. Here a new questionnaire, the CABI, is proposed, and it is validated in a population of 8-10 year-old children. Compared to existing questionnaires, the CABI has been organized so as to be of medium length, with items concerning the most significant symptoms indicated by the DSM-IV-TR for the pertinent disorders, and covering a wider range than existing instruments. There is no charge for its use.The answers of the parents of 302 children in the last 3 years of primary school provided the normative data. A discriminant validation was done for internalizing and externalizing disorders and as a comparison with self-administered anxiety and depression scales. Exploratory factor analysis and internal consistency were also performed.Distribution of scores on the main scales in the normal population shows positive skewness, with the most frequent score being zero. A highly discriminant capability was found in regard to the sample of children with internalizing and externalizing disorders, with high correlation with the self-administered anxiety and depression scales.The CABI appears to be capable, at least for 8-10 year-old children, of effectively discriminating those with pathological symptoms from those without. Compared with the widely- used CBCL, it has the advantages of a lower number of items, which should facilitate parental collaboration especially in epidemiological studies, and of being free of charge. HubMed – depression

 

Effects of fatty acid provision during severe hypoxia on routine and maximal performance of the in situ tilapia heart.

J Comp Physiol B. 2013 Mar 29;
Speers-Roesch B, Lague SL, Farrell AP, Richards JG

The ability to maintain stable cardiac function during environmental hypoxia exposure is crucial for hypoxia tolerance in animals and depends upon the maintenance of cardiac energy balance as well as the state of the heart’s extracellular environment (e.g., availability of metabolic fuels). Hypoxic depression of plasma [non-esterified fatty acids] (NEFA), an important cardiac aerobic fuel, is a common response in many species of hypoxia-tolerant fishes, including tilapia. We tested the hypothesis that decreased plasma [NEFA] is important for maintaining stable cardiac function during and following hypoxia exposure, based on the premise that continued reliance upon cardiac fatty acid metabolism under such conditions could impair cardiac function. We examined the effect of severe hypoxia exposure (PO2 < 0.2 kPa) on routine and maximum performance of the in situ perfused tilapia heart under conditions of routine (400 ?mol L(-1)) and low (75 ?mol L(-1)) [palmitate], which mimicked the in vivo levels of plasma [NEFA] found in normoxic and hypoxic tilapia, respectively. Under both concentrations of palmitate, the in situ tilapia heart showed exceptional hypoxic performance as a result of a high maximum glycolytic potential, confirming our previous results using a perfusate without fatty acids. We additionally provide evidence suggesting that non-contractile ATP demand is depressed in tilapia heart during hypoxia exposure. Cardiac performance during and following severe hypoxia exposure was unaffected by the level of palmitate. Thus, we conclude that hypoxic depression of plasma [NEFA] in fishes does not play a role in cardiac hypoxia tolerance. HubMed – depression

 

CHILDHOOD TEMPERAMENT-BASED ANTICIPATORY GUIDANCE IN AN HMO SETTING: A LONGITUDINAL STUDY.

J Community Psychol. 2013 Mar; 41(2): 236-248
Cameron JR, Rice DC, Sparkman G, Neville HF

This study investigates whether individualized, anticipatory temperament guidance could benefit the parent-child relationship and improve children’s mental health over time. Parents of preschoolers in a health management organization completed a temperament questionnaire, received written parenting information tailored to their child’s temperament, and were asked to complete a program evaluation questionnaire. The numbers of subsequent visits to the pediatric and psychiatry departments with anxiety, depression, attention deficit hyperactivity disorder, and other externalizing behavior diagnoses were compared over 15 years to a control sample that received only standard care. Parents positively reviewed the program and boys who received the intervention had fewer visits with psychiatric diagnoses. Analyses revealed an interaction effect, where boys with harder-to-manage temperaments saw a greater reduction in visits from the intervention. By sensitizing parents to their child’s temperament and helping parents understand and manage temperament-related behaviors, anticipatory guidance can encourage a positive parent-child relationship and reduce future occurrences of psychiatric diagnoses. HubMed – depression

 

Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger Jacob in the rat brain.

Brain Struct Funct. 2013 Mar 29;
Mikhaylova M, Karpova A, Bär J, Bethge P, Yuanxiang P, Chen Y, Zuschratter W, Behnisch T, Kreutz MR

In previous work, we found that the protein messenger Jacob is involved in N-methyl-D-aspartate receptor (NMDAR) signaling to the nucleus and cAMP response element-binding protein (CREB) mediated gene expression in hippocampal primary neurons. Particularly, extrasynaptic NMDAR activation drives Jacob efficiently into the nucleus where it then induces gene expression that promotes neurodegeneration. However, the protein also translocates to the nucleus in CA1 neurons after Schaffer collateral long-term potentiation (LTP) but not long-term depression (LTD), suggesting that Jacob might be involved in hippocampal and LTP-dependent learning and memory processes. Not much is known about the cellular and subcellular distribution of the protein in brain. In this paper, we provide an overview of the expression of Jacob in rat brain with special emphasis on the hippocampus. We show that Jacob is abundant in hippocampal pyramidal neurons and interneurons but absent from astrocytes and microglia. Interestingly, we found that Jacob is also present in mossy fiber axons. Double immunofluorescence confocal laser scans with presynaptic markers demonstrate that Jacob is indeed found at excitatory but not inhibitory presynaptic sites. Accordingly, we found no substantial co-localization of Jacob with a postsynaptic marker of inhibitory synapses, gephyrin. In contrast, almost all postsynaptic density protein 95 (PSD-95) positive excitatory postsynaptic sites also exhibited strong Jacob-immunofluorescence. Taken together, these data support a synaptic and nuclear role of Jacob that implicates long-distance NMDAR signaling to the nucleus in excitatory neurons. HubMed – depression

 


 

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