Georgian Med News. 2013 May; 40-44
Ryndina N, Kravchun P, Tytova G, Liepieieva O

Anemia and renal dysfunction are considered as predictors of an unfavorable course of chronic heart failure, the presence of depressive disorders in these patients is a risk factor for recurrent hospitalizations and deaths. The aim – study of morphological and functional changes in the myocardium, as well as the assessment of the existence and character of depressive disorders in patients with anemia varying grades of severity, developed on a background of chronic heart failure and chronic kidney disease. Structural and functional parameters of myocardium were investigated by echocardioscopy. Beck Depression Inventory was used to assess the presence and character of depressive disorders. The progression of anemic syndrome was accompanied by dilation of the left and right cavities of heart, inotropic function decreasing. In patients with anemic syndrome on a base of chronic heart failure and chronic kidney disease depressive disorders are observed mainly due to the cognitive-affective disorders in 1st grade anemia, and their combination with somatic manifestations of depression in patients with anemia of 2d and 3d grade. HubMed – depression


The Psychological Defensive Profile of Hemodialysis Patients and Its Relationship to Health-Related Quality of Life.

J Nerv Ment Dis. 2013 Jun 19;
Carvalho AF, Ramírez SP, Macêdo DS, Sales PM, Rebouças JC, Daher EF, Hyphantis TN

Preliminary data suggest that defensive profile of hemodialysis (HD) patients might influence adaptation to the disease. However, the association of defense mechanisms with health-related quality of life (HRQoL) of HD patients remains unknown. In this cross-sectional investigation, 170 HD patients and 170 age- and sex-matched healthy participants had their psychological profile assessed with the Defense Style Questionnaire-40 and the Hospital Anxiety and Depression Scale. Furthermore, the HD patients had their HRQoL measured with the World Health Organization Quality of Life instrument-abbreviated version. The HD patients had a more neurotic and immature defensive profile. Splitting, projection, reaction formation, and denial were significantly associated with impaired HRQoL, independent of psychological distress. Somatization was an independent correlate of worse overall and physical HRQoL. These findings suggest that, apart from the treatment of psychological distress symptoms, clinicians should also consider the defensive profile of HD patients because it is independently associated with HRQoL and may be amenable to treatment. HubMed – depression


A prospective study of the bi-directional association between vision loss and depression in the elderly.

J Affect Disord. 2013 Jun 17;
Carrière I, Delcourt C, Daien V, Pérès K, Féart C, Berr C, Laure Ancelin M, Ritchie K

Increasing visual impairment (VI) with age has been associated with mental health problems but the question of temporal direction and reverse causality has not been addressed previously. Our objective was to prospectively examine the bi-directional association of VI and visual function (VF) loss with depressive symptoms in the elderly.The cohort comprised 4216 participants (40.2% men) aged 65 and over with 10 years of follow-up. Near VI was defined using measured usual-corrected binocular acuity while distance VF was self-declared. Participants having a major depressive episode or a Center for Epidemiologic Studies Depression Scale score ?16 were classified as having depressive symptomatology. Longitudinal analyses used mixed logistic models for repeated evaluations.After adjustment for demographic factors, participants with moderate to severe near VI at baseline had increased odds of developing depressive symptomatology (Odds Ratio [OR]=1.60; 95% Confidence Interval [CI]=1.08-2.38), but after multiple adjustments the association fell below the significance level. A 2-year decrease in distance VF was associated with increased odds of depressive symptomatology during follow-up after multiple adjustments (OR=3.03; 95% CI=1.75-5.23). Baseline depressive symptomatology was not associated with incident near VI but was associated with VF loss after multivariate adjustment (OR=1.62; 95% CI=1.15-2.28).The causes of VI have not been recorded.The relation of vision loss to onset of depressive symptomatology differs according to near VI or distance VF and declines across time. A reverse strong association was found between baseline depression and incident loss of distance VF suggesting a downward spiral of events. HubMed – depression


Prediction of the time-course pattern of remission in depression by using clinical, neuropsychological, and genetic variables.

J Affect Disord. 2013 Jun 17;
Gudayol-Ferré E, Guàrdia-Olmos J, Peró-Cebollero M, Herrera-Guzmán I, Camarena B, Cortés-Penagos C, Herrera-Abarca JE, Martínez-Medina P

The prediction of remission in pharmacologically-treated MDD patients has been scarcely studied. The goal of our work is to study the possible effect of clinical variables, neuropsychological performance, and the 5HTTLPR, the rs25531 of the SLC6A4 gene, and the val108/58Met of the COMT gene polymorphisms on the prediction of the speed of remission in MDD patients.Seventy-two depressed patients were genotyped according to the aforementioned polymorphisms and were clinically and neuropsychologically assessed before a 12-week fluoxetine treatment.From this original sample 51 patients were considered as remitters at the end of week 12. Thirteen out of those showed a rapid response pattern, 24 showed an oscillating response pattern, and 14 showed a slow response pattern. The following variable combination is capable of showing a statistically significant relationship with the pattern of remission of patients with MDD: initial Hamilton score, age at first depressive episode, AG and GG alleles of the val108/58Met COMT polymorphism, Stroop PC, and SWM Strategy.We have a slightly small sample size, which came to prominence during the data analysis since we were working with 3 subgroups. In this study, the placebo effect has not been controlled.Our data suggest that the patients with MDD who remit after a 12-week treatment with fluoxetine show one of the following time-course patterns: a rapid symptomatic improvement, or a slow or oscillating pattern of remission. A combination of clinical, neuropsychological, and genetic variables allows us to predict these response patterns. HubMed – depression