Association of the Neuronal Cell Adhesion Molecule (NrCAM) Gene Variants With Personality Traits and Addictive Symptoms in Methamphetamine Use Disorder.

Association of the Neuronal Cell Adhesion Molecule (NrCAM) Gene Variants with Personality Traits and Addictive Symptoms in Methamphetamine Use Disorder.

Filed under: Addiction Rehab

Psychiatry Investig. 2012 Dec; 9(4): 400-7
Yoo BK, Shim JC, Lee BD, Kim C, Chung YI, Park JM, Kim SG, Kim JH, Lee YM, Moon ES, Kwon do H

1) To investigate the relationship between NrCAM polymorphisms and methamphetamine abuse in an ethnically homogenous Korean population. 2) To further support our findings by investigating the association among NrCAM gene variants, certain personality traits, and addictive symptoms of methamphetamine abusers.Thirty-seven male methamphetamine abusers (age=43.3±7.8) and30 non-users (16 men, 14 women; age=59.8±10.4) were recruited. Ten single nucleotide polymorphisms (SNPs) in the NrCAM gene were assayed to compare genotype distributions between the 2 groups. Personality characteristics were measured using the Temperament and Character Inventory (TCI) and the NEO Personality Inventory, Revised (NEO PI-R). Addictive symptoms were assessed using the Diagnostic Interview for Genetic Studies (DIGS) and reviews of the subject’s medical records.Among the 10 SNPs in the NrCAM gene, the frequency of the TA genotype at rs1990162 was significantly lower in methamphetamine abusers compared to non-users (p=0.042). In the 3 NrCAM gene SNPs (rs381318, rs2072546, and rs6954366), the distribution of genotypes and alleles were significantly associated with some traits in the TCI and NEO PI-R. Genotypes and alleles at 5 gene SNPs (rs2142325, rs381318, rs1269621, rs1269634, and rs1990162) were associated with certain addictive symptom dimensions in the patients.These findings support the idea that NrCAM is associated with genetic susceptibility of methamphetamine abuse and is also associated with certain personality characteristics that may increase disturbed addictive behavior.
HubMed – addiction


Standardization study of internet addiction improvement motivation scale.

Filed under: Addiction Rehab

Psychiatry Investig. 2012 Dec; 9(4): 373-8
Park JW, Park KH, Lee IJ, Kwon M, Kim DJ

The purpose of this study was to develop a scale to measure motivation to improve Internet addiction. Motivation is known to be important to treat Internet addiction successfully. The reliability of the scale was assessed, and its concurrent validity was evaluated.Ninety-two adolescents participated in this study. The basic demographic characteristics were recorded and the Korean version of the Stages of Readiness for Change and Eagerness for Treatment Scale for Internet Addiction (K-SOCRATES-I) was administered. Subsequently, the Internet Addiction Improvement Motivation Scale was developed using 10 questions based on the theory of motivation enhancement therapy and its precursor version designed for smoking cessation.The motivation scale was composed of three subscales through factor analysis; each subscale had an adequate degree of reliability. In addition, the motivation scale had a high degree of validity based on its significant correlation with the K-SOCRATES-I. A cut-off score, which can be used to screen out individuals with low motivation, was suggested.The Internet Addiction Improvement Motivation Scale, composed of 10 questions developed in this study, was deemed a highly reliable and valid scale to measure a respondent’s motivation to be treated for Internet addiction.
HubMed – addiction


From occasional choices to inevitable musts: a computational model of nicotine addiction.

Filed under: Addiction Rehab

Comput Intell Neurosci. 2012; 2012: 817485
Metin S, Sengor NS

Although, there are considerable works on the neural mechanisms of reward-based learning and decision making, and most of them mention that addiction can be explained by malfunctioning in these cognitive processes, there are very few computational models. This paper focuses on nicotine addiction, and a computational model for nicotine addiction is proposed based on the neurophysiological basis of addiction. The model compromises different levels ranging from molecular basis to systems level, and it demonstrates three different possible behavioral patterns which are addict, nonaddict, and indecisive. The dynamical behavior of the proposed model is investigated with tools used in analyzing nonlinear dynamical systems, and the relation between the behavioral patterns and the dynamics of the system is discussed.
HubMed – addiction



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