Apolipoprotein E Gene, Environmental Risk Factors, and Their Interactions in Dementia Among Seniors.

Apolipoprotein E gene, environmental risk factors, and their interactions in dementia among seniors.

Filed under: Depression Treatment

Int J Geriatr Psychiatry. 2012 Dec 17;
Meng X, D’Arcy C

OBJECTIVES: Little research has been conducted to explore the joint effect of apolipoprotein E (ApoE) genotypes and environmental risk factors on dementia. In this study, we examined the roles of ApoE alleles and genotypes in dementia and cognitively impaired not demented (CIND), assessed the risk of co-existing or prior health conditions (i.e. depression), family history of diseases, and lifestyle factors on dementia, and explored the interactions between genetic and environmental risk factors and their joint effects on dementia and cognitive impairment. METHODS: This is a genetic association study. A total of 1185 seniors (391 dementia, 389 CIND, and 405 cognitively intact, matched for age and gender) were selected from the Canadian Study of Health and Aging clinical assessment datasets. Multivariate logistic regression was used to explore the association between ApoE, environment risk factors, and outcomes. RESULTS: Participants with ApoE ?4 alleles or ?3/?4 genotypes were at risk of dementia. More education reduced the risk of dementia or CIND. Previous health conditions (e.g. stroke) increased the risk of dementia or CIND. Regular exercise decreased the risk of CIND. ApoE ?3/?4 genotype and baseline depression had a 7.97-fold greater risk of incident dementia after adjusting for other significant risk factors. No interactions were found in any dementia and CIND models. CONCLUSIONS: More attention should be paid to assess and treat depressed older people, especially for those with ApoE ?3/?4 genotypes. Further replication studies in different populations are warranted. Copyright © 2012 John Wiley & Sons, Ltd.
HubMed – depression

The association between self-reported daily hassles and cortisol levels in depression and anxiety in community living older adults.

Filed under: Depression Treatment

Int J Geriatr Psychiatry. 2012 Dec 17;
Vasiliadis HM, Forget H, Préville M

OBJECTIVES: The aim of this study was to assess whether the association, in a naturalistic setting, between daily hassles and diurnal salivary cortisol differs in the presence of depression and anxiety in older adults. METHODS: Data were assessed in a large representative community sample of older adults (n?=?1760). A multinomial analysis was used to study as an outcome variable: no disorder, depression only, anxiety only and depression and anxiety, as a function of daily hassles and cortisol levels controlling for age, gender and time of saliva collection. Multivariate regression analyses were also carried out to test the association between daily hassles and cortisol levels stratified by depression and anxiety status. RESULTS: A significant positive association was observed between the number of daily hassles reported and cortisol levels in participants with no depression and no anxiety and in participants with anxiety. Participants without depression and anxiety, and those with depression only, had significant lower cortisol levels later in the day. This was not observed in respondents with anxiety. CONCLUSION: Stressors such as daily hassles are associated with cortisol secretion in depression and anxiety in older adults in a large epidemiologic setting. Copyright © 2012 John Wiley & Sons, Ltd.
HubMed – depression

Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer’s disease.

Filed under: Depression Treatment

Int J Geriatr Psychiatry. 2012 Dec 17;
Van der Mussele S, Bekelaar K, Le Bastard N, Vermeiren Y, Saerens J, Somers N, Mariën P, Goeman J, De Deyn PP, Engelborghs S

BACKGROUND: Mild cognitive impairment (MCI) is a clinical concept that categorizes subjects who are in an intermediate cognitive state between normal aging and dementia. The aims of this study are to determine the prevalence of significant depressive symptoms in MCI and Alzheimer’s disease (AD) patients and to characterize the behavior associated with significant depressive symptoms in MCI and AD patients. METHODS: A cross-sectional analysis of baseline data from a prospective, longitudinal study on behavioral symptoms of dementia and MCI was performed. The study population consisted of 270 MCI and 402 AD patients. Behavioral assessment was performed by means of Middelheim Frontality Score, Behavioral Pathology in Alzheimer’s Disease Rating Scale (Behave-AD) and Cohen-Mansfield Agitation Inventory. The presence of significant depressive symptoms was defined as a Cornell Scale for Depression in Dementia total score >7. RESULTS: The prevalence of significant depressive symptoms in AD patients (25%) was higher compared with MCI patients (16%) (p?=?0.005). Patients with significant depressive symptoms showed an increased severity of frontal lobe symptoms, behavioral symptoms and agitation (Middelheim Frontality Score, Behave-AD and Cohen-Mansfield Agitation Inventory total scores; p?HubMed – depression

Treatment Plans and Interventions for Depression and Anxiety Disorders
Includes CD-ROM with Reproducible Forms!This one-of-a-kind resource provides the busy practitioner with empirically supported trea…

How to Break the Grip of Depression: Read How Robert Declared War On Depression … And Beat It!
Depression is not an antidepressant deficiency! Depression is the most common mood disorder in the world and in all likelihood one…

Treatment Resistant Depression: A Roadmap for Effective Care
This unique book presents the treatment “roadmap” implemented by the University of Michigan Comprehensive Depression Center’s Trea…

Related Depression Treatment Information…