Angst: Origins of Anxiety and Depression.
Angst: Origins of Anxiety and Depression.
Am J Psychiatry. 2013 Jul 1; 170(7): 809-810
Parker G
SLC6A15 rs1545843 and Depression: Implications From Brain Imaging Data.
Am J Psychiatry. 2013 Jul 1; 170(7): 805
Li M, Ge T, Feng J, Su B
Whole-Body Hyperthermia for the Treatment of Major Depression: Associations With Thermoregulatory Cooling.
Am J Psychiatry. 2013 Jul 1; 170(7): 802-804
Hanusch KU, Janssen CH, Billheimer D, Jenkins I, Spurgeon E, Lowry CA, Raison CL
Late-Onset Agoraphobia: General Population Incidence and Evidence for a Clinical Subtype.
Am J Psychiatry. 2013 Jul 1; 170(7): 790-798
Ritchie K, Norton J, Mann A, Carrière I, Ancelin ML
OBJECTIVE The purpose of this study was to estimate the general population incidence of late-life agoraphobia and to define its clinical characteristics and risk factors. METHOD A total of 1,968 persons ?65 years old were randomly recruited from the electoral rolls of the district of Montpellier, France. Prevalent and incident agoraphobia diagnosed with a standardized psychiatric examination and validated by a clinical panel were assessed at baseline and over a 4-year follow-up. RESULTS The 1-month baseline prevalence of agoraphobia was estimated to be 10.4%. Among persons with agoraphobia, 10.9% reported having their first episode at age 65 or above. During the 4-year follow-up, 11.2% of participants without agoraphobia at baseline had a first episode, resulting in an incidence rate of 32 per 1,000 person-years. These 132 incident late-onset cases were associated with higher incidence rates of anxiety disorders and suicidal ideation. Of the incident cases, only two were characterized by past or concurrent panic attacks, a rate that was not significantly different from that of the noncase group. The principal baseline risk factors for incident cases, derived from a multivariate model incorporating all significant risk factors, were younger age at onset (odds ratio=0.94, 95% CI=0.90-0.99), poorer visuospatial memory performance (odds ratio=1.60, 95% CI=1.02-2.49), severe depression (odds ratio=2.62, 95% CI=1.34-5.10), and trait anxiety (odds ratio=1.73, 95% CI=1.03-2.90). No significant association was found with cardiac pathologies. CONCLUSIONS Agoraphobia has a high prevalence in the elderly, and unlike cases in younger populations, late-onset cases are not more common in women and are not associated with panic attacks, suggesting a late-life subtype. Severe depression, trait anxiety, and poor visuospatial memory are the principal risk factors for late-onset agoraphobia. HubMed – depression