Addiction Rehab: Voxel-Based Imaging of Translocator Protein 18kDa (TSPO) in High-Resolution PET.

Voxel-based imaging of translocator protein 18kDa (TSPO) in high-resolution PET.

Filed under: Addiction Rehab

J Cereb Blood Flow Metab. 2013 Jan 2;
Ko JH, Koshimori Y, Mizrahi R, Rusjan P, Wilson AA, Lang AE, Houle S, Strafella AP

In vivo imaging of translocator protein 18?kDa (TSPO) has received significant attention as potential biomarker of microglia activation. Several radioligands have been designed with improved properties. Our group recently developed an (18)F-labeled TSPO ligand, [(18)F]-FEPPA, and confirmed its reliability with a 2-tissue compartment model. Here, we extended, in a group of healthy subjects, its suitability for use in voxel-based analysis with the newly proposed graphical analysis approach, Relative-Equilibrium-Gjedde-Patlak (REGP) plot. The REGP plot successfully replicated the total distribution volumes estimated by the 2-tissue compartment model. We also showed its proof-of-concept in a patient with possible meningioma showing increased [(18)F]-FEPPA total distribution volume.Journal of Cerebral Blood Flow & Metabolism advance online publication, 2 January 2013; doi:10.1038/jcbfm.2012.203.
HubMed – addiction


A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents.

Filed under: Addiction Rehab

ChemMedChem. 2012 Dec 20;
Chen H, Wang CZ, Ding C, Wild C, Copits B, Swanson GT, Johnson KM, Zhou J

PAMs new in town! An effective, combined bioinformatics and chemoinformatics approach was applied to the design of novel asymmetric bivalent ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric modulators (PAMs) with marked potency in?vitro and efficacy in?vivo for preventing neuroapoptosis. The novel chemotype could provide pharmacological probes and potential therapeutic agents for glutamatergic hypofunction and its related neurological and psychiatric disorders.
HubMed – addiction


Disparities in unmet need for mental health services in the United States, 1997-2010.

Filed under: Addiction Rehab

Psychiatr Serv. 2013 Jan 1; 64(1): 80-2
Roll JM, Kennedy J, Tran M, Howell D

OBJECTIVES This study estimated unmet need for mental health services, identified population risk factors related to unmet need, and established baseline data to assess the impact of the Affordable Care Act (ACA) and the Mental Health Parity and Addiction Equity Act. METHODS National Health Interview Survey data (1997-2010) were analyzed. RESULTS Unmet need increased from 4.3 million in 1997 to 7.2 million in 2010. Rates in 2010 were about five times higher for uninsured than for privately insured persons. In a multivariate logistic model, likelihood was higher among children (age two to 17), working-age adults (age 18-64), women, uninsured persons, persons with low incomes, in fair or poor health, and with chronic conditions. CONCLUSIONS Unmet need is widespread, particularly among the uninsured. Expansion of coverage under the ACA, in conjunction with federal parity, should improve access, but ongoing monitoring of access is a research and policy priority.
HubMed – addiction



Addiction Rehab Success Story – California CA – An alcoholic and drug Addict goes to rehab in California CA and overcomes his drug addiction.


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