Acquired Inhibitors: A Special Case of Bleeding in Older Adults.

Acquired inhibitors: a special case of bleeding in older adults.

Filed under: Drug and Alcohol Rehabilitation

Curr Gerontol Geriatr Res. 2012; 2012: 308109
Stefanacci RG

This literature review is intended to familiarize physicians and healthcare providers of older adults with the potential causes of acute bleeding in older adults and to review diagnostic approaches that can produce prompt identification of acute bleeding and facilitate timely treatment. Adverse events from anticoagulant treatment and nonsteroidal anti-inflammatory drug (NSAID) and aspirin use and abuse are among the most common causes of bleeding in older adults. Diagnoses infrequently considered-mild congenital hemophilia, acquired hemophilia, von Willebrand disease, and platelet dysfunction-can contribute to acute bleeding in older adults. The approach to management of bleeding varies. Management of acute bleeding in older adults can be challenging because these patients often have chronic comorbidity and have been prescribed long-term concomitant medications that can complicate diagnosis and treatment. Prompt recognition of acquired hemophilia, referral to an expert hematologist, and timely initiation of treatment could improve outcome in older patients who experience bleeding episodes resulting from this condition.
HubMed – drug


Preclinical Determinants of Drug Choice under Concurrent Schedules of Drug Self-Administration.

Filed under: Drug and Alcohol Rehabilitation

Adv Pharmacol Sci. 2012; 2012: 281768
Banks ML, Negus SS

Drug self-administration procedures have played a critical role in the experimental analysis of psychoactive compounds, such as cocaine, for over 50 years. While there are numerous permutations of this procedure, this paper will specifically focus on choice procedures using concurrent schedules of intravenous drug self-administration. The aims of this paper are to first highlight the evolution of drug choice procedures and then review the subsequent preclinical body of literature utilizing these choice procedures to understand the environmental, pharmacological, and biological determinants of the reinforcing stimulus effects of drugs. A main rationale for this paper is our proposition that choice schedules are underutilized in investigating the reinforcing effects of drugs in assays of drug self-administration. Moreover, we will conclude with potential future directions and unexplored scientific space for the use of drug choice procedures.
HubMed – drug


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