[Influence of Methylenetetrahydrofolate Reductase Gene Polymorphisms on Antidepressant Response].

[Influence of methylenetetrahydrofolate reductase gene polymorphisms on antidepressant response].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013 Feb; 30(1): 26-30
Sun X, Zhang Z, Shi Y, Xu Z, Pu M, Geng L

To assess the influence of polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene on response to antidepressant treatment.Two hundred and eight one Chinese Han patients have received single antidepressant drugs for at least 6 weeks, among whom 275 were followed up for 8 weeks. Hamilton depression scale 17 (HAMD-17) was used to evaluate the severity of depressive symptoms and therapeutic effects. Single nucleotide polymorphisms (SNPs) of the MTHFR gene were determined using gene chips. Associations of single loci and haplotypes with response to treatment were analyzed using an Unphased 3.0.13 software.No significant differences in gender, age, year of education, family history, episode times, and antidepressant agents were found between responders and non-responders (all P U+003E 0.05), while the baseline scores of HAMD-17 was significantly different(t=2.891, P=0.004). There was also no significant difference between age, years of education, family history, baseline scores of HAMD-17 and antidepressant agents between remitters and non-remitters (both P U+003E 0.05), while proportion of male patients was significantly higher in non-remission group than remission group (t=2.381, P=0.018), and episode times in non-remission group was significantly higher (t=-1.983, P=0.049). Single locus association analysis has found no significant association between SNPs rs1801131 and rs1801133 in the MTHFR gene with antidepressant response (P U+003E 0.05). On the other hand, haplotype A-C of MTHFR gene (rs1801131 and rs1801133) was significantly associated with antidepressant response in total group (U+03C7 =11.39, P=0.0007), male subgroup (U+03C7 =8.767, P=0.003) and serotonin noradrenaline reuptake inhibitors (SNRIs) subgroup (U+03C7 =10.51, P=0.001).Particular haplotype of MTHFR gene may be related with antidepressant effect, in which the haplotype (rs1801131, rs1801133) A-C type may be associated with better antidepressant efficacy, particularly in males and patients receiving SNRIs drugs. HubMed – depression


Is gait speed a valid measure to predict community ambulation in patients with Parkinson’s disease?

J Rehabil Med. 2013 Feb 28;
Elbers RG, van Wegen EE, Verhoef J, Kwakkel G

Objective: To investigate the predictive value of gait speed for community walking in Parkinson’s disease and to develop a multivariate prediction model for community walking. Design: Data from baseline assessments in a randomized clinical trial were used. Subjects: A total of 153 patients with Parkinson’s disease were included. Methods: Community walking was evaluated using the mobility domain of the Nottingham Extended Activities of Daily Living Index (NEAI). Patients who scored 3 points on item 1 (“Did you walk around outside?”) and item 5 (“Did you cross roads?”) were considered community walkers. Gait speed was measured with the 6-m or 10-m timed walking test. Age, gender, marital status, disease duration, disease severity, motor impairment, balance, freezing of gait, fear of falling, previous falls, cognitive function, executive function, fatigue, anxiety and depression were investigated for their contribution to the multivariate model. Results: Seventy patients (46%) were classified as community walkers. A gait speed of 0.88 m/s correctly predicted 70% of patients as community walkers. The multivariate model, including gait speed and fear of falling, correctly predicted 78% of patients as community walkers. Conclusion: Timed walking tests are valid measurements to predict community walking in Parkinson’s disease. However, evaluation of community walking should include an assessment of fear of falling. HubMed – depression


One-year course and effects of insomnia in rural chinese adolescents.

Sleep. 2013; 36(3): 377-84
Luo C, Zhang J, Pan J

We aimed to explore the incidence and persistence of insomnia, the associated risk factors, and the potential bidirectional association of insomnia with depression, anxiety, and sleepiness in rural Chinese adolescents.School-based prospective study.Five high schools in rural China.There were 2,787 adolescents studied.N/A.Insomnia was defined as having a score of equal to or higher than nine in the Insomnia Severity Index as validated in Chinese adolescents. Depression, anxiety, and sleepiness were determined by the Beck Depression Inventory (BDI), Zung Self-Rating Anxiety Scale (SAS), and Epworth Sleepiness Scale (ESS), respectively. The incidence and persistence rates of insomnia were 16.0% and 41.0%, respectively. Multivariate analyses in logistic regression models revealed that new incidence of insomnia was significantly associated with age, living in a rural area, habitual daytime napping, high life events, anxiety, and depression at baseline (range adjusted odds ratio = 1.12-1.61), whereas the persistence of insomnia was positively associated with age, female sex, high life events, and depression at baseline (range adjusted odds ratio = 1.26-1.55) but negatively associated with living in a rural area (odds ratio = 0.59). Insomnia at baseline could predict new onsets of both depression (odds ratio = 1.45) and anxiety (odds ratio = 1.98) but not sleepiness at follow-up after adjustment for age, sex, and baseline symptoms. The results in cross-lagged analyses further supported these observations in the bidirectional associations of insomnia with depression, anxiety, and sleepiness.Insomnia has considerable incidence and persistence rates in Chinese adolescents. We have identified several risk factors for the incidence and persistence of insomnia. There are bidirectional associations of insomnia with depression and anxiety but not sleepiness. CITATION: Luo C; Zhang J; Pan J. One-year course and effects of insomnia in rural Chinese adolescents. 2013;36(3):377-384. HubMed – depression