Treatment of Experimental Ulcerative Colitis.
Treatment of experimental ulcerative colitis.
Filed under: Drug and Alcohol Rehabilitation
Bull Exp Biol Med. 2012 Oct; 153(6): 889-92
Lazebnik LB, Lychkova AE, Knyazev OV
The effects of infliximab, an anticytokine drug, on the course of inflammatory process was studied on the model of ulcerative colitis induced by injection of picrylsulfonic acid. Infliximab prevented the development of toxic dilatation and a drop of bioelectric activity of smooth muscles via maintenance of activity of the intramural nervous system neurons.
HubMed – drug
Expression of Vascular Endothelial Growth Factor Receptors VEGFR1 in Cultured Multiple Myeloma Cells: Correlation with Immunophenotype and Drug Resistance.
Filed under: Drug and Alcohol Rehabilitation
Bull Exp Biol Med. 2012 Oct; 153(6): 882-5
Kalitin NN, Kostyukova MN, Kakpakova ES, Tupitsyn NN, Karamysheva AF
We studied the expression of genes encoding vascular endothelial growth factors VEGF-A, VEGF-C, VEGF-D and their receptors in cell cultures of human multiple myeloma IM9, RPMI 1640, RPMI 8226. The studied cells did not differ by the expression of growth factors. Expression of VEGFR1 receptor was detected only in IM9 cells and VEGFR2 and VEGFR3 receptors were not expressed in multiple myeloma cells. A dependence between the aberrant CD45/CD56 phenotype of human multiple myeloma cells and VEGFR1 expression in them was revealed. The only VEGFR1-positive IM9 cell culture was most resistant to Velcade (bortezomib).
HubMed – drug
Expression of Peroxiredoxin 1, 2, 3, and 6 Genes in Cancer Cells during Drug Resistance Formation.
Filed under: Drug and Alcohol Rehabilitation
Bull Exp Biol Med. 2012 Oct; 153(6): 878-81
Kalinina EV, Berezov TT, Shtil’ AA, Chernov NN, Glazunova VA, Novichkova MD, Nurmuradov NK
We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the important contribution of redox-dependent mechanisms into the development of cisplatin resistance of cancer cells.
HubMed – drug
Effect of triterpene derivatives on the total hepatocyte count in the liver of rats with toxic hepatitis.
Filed under: Drug and Alcohol Rehabilitation
Bull Exp Biol Med. 2012 Oct; 153(6): 858-61
Semenov DE, Zhukova NA, Bessergeneva EP, Sorokina IV, Baev DS, Glukhov BM, Nepomnyaschikh GI, Tolstikova TG
We studied hepatoprotective activity of betulonic acid and its alaninamide on the model of combined CCl(4)- and ethanol-induced toxic liver damage in rats. The test substances, especially betulonic acid alaninamide, considerably reduced the elevated biochemical parameters in animals with toxic liver damage. Betulonic acid alaninamide also stimulated reparative processes in the liver (activated hepatocyte proliferation). Heptral (reference drug) produced no appreciable effects on the reparative processes. Our findings suggest that betulin derivatives exhibit pronounced protective properties.
HubMed – drug
Effects of tenoten on anxiety and depression disorders in patients with epilepsy.
Filed under: Drug and Alcohol Rehabilitation
Bull Exp Biol Med. 2012 Sep; 153(5): 704-6
Delger AB, Avakyan GN, Oleinikova OM, Bogomazova MA, Chromych EA, Lagutin IuV
The efficiency and safety of tenoten for anxiety and depression disorders in epileptics has been demonstrated. The drug does not change the incidence and severity of epileptic episodes, does not deteriorate the course of the underlying disease, and can be well combined with anticonvulsants. The results indicate the efficiency of tenoten used to arrest the anxio-depressive disorders in epilepsy.
HubMed – drug
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