Rehab Centers: Marrow Fat and Bone–New Perspectives.

Marrow Fat and Bone–New Perspectives.

Filed under: Rehab Centers

J Clin Endocrinol Metab. 2013 Feb 7;
Fazeli PK, Horowitz MC, Macdougald OA, Scheller EL, Rodeheffer MS, Rosen CJ, Klibanski A

Context:There is growing interest in the relationship between bone mineral density, bone strength, and fat depots. Marrow adipose tissue, a well-established component of the marrow environment, is metabolically distinct from peripheral fat depots, but its functional significance is unknown.Objective:In this review, we discuss animal and human data linking the marrow adipose tissue depot to parameters of bone density and integrity as well as the potential significance of marrow adipose tissue in metabolic diseases associated with bone loss, including type 1 diabetes mellitus and anorexia nervosa. Potential hormonal determinants of marrow adipose tissue are also discussed.Conclusions:We conclude that whereas most animal and human data demonstrate an inverse association between marrow adipose tissue and measures of bone density and strength, understanding the functional significance of marrow adipose tissue and its hormonal determinants will be critical to better understanding its role in skeletal integrity and the role of marrow adipose tissue in the pathophysiology of bone loss.
HubMed – rehab

 

Less-Invasive Semitendinosus Tendon Graft Augmentation for the Reconstruction of Chronic Tears of the Achilles Tendon.

Filed under: Rehab Centers

Am J Sports Med. 2013 Feb 7;
Maffulli N, Del Buono A, Spiezia F, Maffulli GD, Longo UG, Denaro V

BACKGROUND:Less-extensive and gentler exposure and dissection of deep soft tissues could reduce the times of recovery and rehabilitation after Achilles tendon reconstruction. HYPOTHESIS:A minimally invasive semitendinosus autologous graft reconstruction of the Achilles tendon preserves skin integrity and reduces wound breakdown. STUDY DESIGN:Case series; Level of evidence, 4. METHODS:A total of 26 patients underwent minimally invasive semitendinosus autologous graft reconstruction for chronic ruptures to the Achilles tendon. Patients underwent a comparison of preoperative versus postoperative maximum calf circumference and isometric plantarflexion strength and evaluation of postoperative complications. The Achilles Tendon Total Rupture Score (ATRS) was administered at the final follow-up appointment. RESULTS:All patients were reviewed at an average of 8.2 years (range, 7-10 years) from surgery. No patient was lost to follow-up. At final follow-up, the maximum calf circumference was significantly higher than preoperatively but significantly lower than the contralateral side. The isometric plantarflexion strength in the operated leg was lower than in the uninjured one. The mean ATRS was 88. Two patients developed a superficial wound infection, both healing within 2 months from the index surgery after systemic antibiotics and local dressings. One patient developed scar adhesion to the distal wound. All patients returned to their preinjury working occupation; 22 patients returned to their preinjury level of activity at a mean of 6.7 months after surgery. CONCLUSION:This technique is minimally invasive, is safe, and allows most of the patients to return to preinjury daily and sport activities within 9 months from surgery.
HubMed – rehab

 

Reduction of Bradykinesia of Finger Movements by a Single Session of Action Observation in Parkinson Disease.

Filed under: Rehab Centers

Neurorehabil Neural Repair. 2013 Feb 7;
Pelosin E, Bove M, Ruggeri P, Avanzino L, Abbruzzese G

BACKGROUND: . Action observation influences motor performance in healthy subjects and persons with motor impairments. OBJECTIVE: . To understand the effects of action observation on the spontaneous rate of finger movements in patients with Parkinson disease (PD). METHODS: . Participants, 20 with PD and 14 healthy controls, were randomly divided into 2 groups. Those in the VIDEO group watched video clips showing repetitive finger movements paced at 3 Hz, whereas those in the ACOUSTIC group listened to an acoustic cue paced at 3 Hz. All participants performed a finger sequence at their spontaneous pace at different intervals (before, at the end of, 45 minutes after, and 2 days after training); 8 participants with PD were recruited for a sham intervention, watching a 6-minute video representing a static hand. Finally, 10 patients participated in the same protocol used for the VIDEO group but were tested in the on and off medication states. RESULTS: . Both VIDEO and ACOUSTIC training increased the spontaneous rate in all participants. VIDEO intervention showed a greater effect over time, improving the spontaneous rate and reducing the intertapping interval to a larger extent than ACOUSTIC 45 minutes and 2 days after training. Action observation significantly influenced movement rate in on and off conditions, but 45 minutes after training, the effect was still present only in the on condition. No effect was observed after sham intervention. CONCLUSIONS: . These findings suggest that the dopaminergic state contributes to the effects of action observation, and this training may be a promising approach in the rehabilitation of bradykinesia in PD.
HubMed – rehab

 

Transcranial Direct Current Stimulation Improves Swallowing Function in Stroke Patients.

Filed under: Rehab Centers

Neurorehabil Neural Repair. 2013 Feb 7;
Shigematsu T, Fujishima I, Ohno K

BACKGROUND: Poststroke dysphagia can persist, leading to many complications. OBJECTIVE: We investigated whether noninvasive brain stimulation to the pharyngeal motor cortex combined with intensive swallowing therapy can improve dysphagia. METHODS: A total of 20 patients who had dysphagia for at least 1 month after stroke were randomly assigned to receive 10 sessions lasting 20 minutes each of either 1-mA anodal transcranial direct current stimulation (tDCS) or a sham procedure to the ipsilesional pharyngeal motor cortex, along with simultaneous conventional swallowing therapies. We evaluated swallowing function with the Dysphagia Outcome and Severity Scale (DOSS) before, immediately after, and 1 month after the last session. RESULTS: Anodal tDCS resulted in an improvement of 1.4 points in DOSS (P = .006) immediately after the last session and 2.8 points (P = .004) 1 month after the last session. The sham tDCS group improved 0.5 points (P = .059) after the last session and 1.2 points (P = .026) 1 month after the final session. The improvements in the anodal tDCS group were significantly greater than those in the sham tDCS group (P = .029 after the last session, and P = .007 1 month after the last session). CONCLUSIONS: Anodal tDCS to the ipsilesional hemisphere and simultaneous peripheral sensorimotor activities significantly improved swallowing function as assessed by the DOSS.
HubMed – rehab

 


 

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