Drug and Alcohol Rehabilitation: Targeted Drug Delivery Using Physical Triggers.
Targeted drug delivery using physical triggers.
Filed under: Drug and Alcohol Rehabilitation
Nanomedicine (Lond). 2012 Oct; 7(10): 1480
Ivankin A, Wanunu M
Regulation of the tumor suppressor PML by sequential post-translational modifications.
Filed under: Drug and Alcohol Rehabilitation
Front Oncol. 2012; 2: 204
Schmitz ML, Grishina I
Post-translational modifications (PTMs) regulate multiple biological functions of the promyelocytic leukemia (PML) protein and also the fission, disassembly, and rebuilding of PML nuclear bodies (PML-NBs) during the cell cycle. Pathway-specific PML modification patterns ensure proper signal output from PML-NBs that suit the specific functional requirements. Here we comprehensively review the signaling pathways and enzymes that modify PML and also the oncogenic PML-RAR? fusion protein. Many PTMs occur in a hierarchical and timely organized fashion. Phosphorylation or acetylation constitutes typical starting points for many PML modifying events, while degradative ubiquitination is an irreversible end point of the modification cascade. As this hierarchical organization of PTMs frequently turns phosphorylation events as primordial events, kinases or phosphatases regulating PML phosphorylation may be interesting drug targets to manipulate the downstream modifications and thus the stability and function of PML or PML-RAR?.
HubMed – drug
Drug discovery and clinical trials: A poem.
Filed under: Drug and Alcohol Rehabilitation
Perspect Clin Res. 2012 Oct; 3(4): 148
Balachandran L
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