Drug and Alcohol Rehabilitation: Biomedical Applications of Dipeptides and Tripeptides.

Biomedical applications of dipeptides and tripeptides.

Filed under: Drug and Alcohol Rehabilitation

Biopolymers. 2012; 98(4): 288-93
Santos S, Torcato I, Castanho MA

Peptides regulate many physiological processes, acting at some sites as endocrine or paracrine signals and at others as neurotransmitters or growth factors, for instance. These molecules represent a major evolution in medical and industrial fields, as it is becoming mandatory to design and exploit molecules that do not necessarily fit the description of classical drug classes. The list of peptides with potential biomedical applications is huge and is growing each year. These biomedical applications range from uses as drugs to flavor-active peptides as ingredients in natural health products, nutraceuticals and functional foods. Among the peptide family, dipeptides and tripeptides are very appealing for drug discovery and development because of their cost-effectiveness, possibility of oral administration, and simplicity to perform molecular structural and quantitative structure-activity studies. Our objective is to review different actual and future uses of dipeptides and tripeptides as well as the major advances and obstacles in this growing area.
HubMed – drug

 

[Analysis on reasons for disapproval of registration application of new traditional Chinese medicines in recent years].

Filed under: Drug and Alcohol Rehabilitation

Zhongguo Zhong Yao Za Zhi. 2012 Aug; 37(15): 2333-7
Zhang X, Zhang L, Wang H

To analyze reasons for disapproval of registration application of new traditional Chinese medicines in recent years and discuss potential problems occurring in R&D and registration administration of new traditional Chinese medicines in China.All applications of new traditional Chinese medicines for registrations that had been disapproved by Center for Drug Evaluation of State Food Drug Administration from 2006 to 2008 were searched in data bank. Specific reasons for disapproval of each variety were inquired and sorted out. The statistics involved the proportion of each type (kind) disapproval reasons in all disapprovals in order to analyze which were the main reasons. The results were analyzed to find out potential problems occurring in R&D and registration administration of new traditional Chinese medicines in China.There were totally 247 disapproved registration applications for new traditional Chinese medicines. Among them, there were 218 applications for clinical trials and 29 applications for launch in the market There were 9 categories (29 types) of reasons for the applications for clinical trials applications, mainly including such problems as R&D proposal, non-clinical effectiveness and non-clinical safety; while there were 5 categories (9 types) of reasons for the applications for launch in the market, with clinical effectiveness as the main reason.There were many kinds of reasons for the disapproval registration applications of new traditional Chinese medicines in recent years in China, mainly including such problems as effectiveness, safety and proposal basis. This reflects problems occurring in R&D and registration administration of new traditional Chinese medicines in China to some extent.
HubMed – drug

 

A special issue of Current Computer-Aided Drug Design honoring Professor Lemont B. Kier on his eightieth birthday.

Filed under: Drug and Alcohol Rehabilitation

Curr Comput Aided Drug Des. 2012 Sep; 8(3): 171-254

HubMed – drug

 


 

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