Depression Treatment: Electrical Impedance of Human Blood With and Without Anticoagulants in the ?-Dispersion Region.

Electrical impedance of human blood with and without anticoagulants in the ?-dispersion region.

Filed under: Depression Treatment

Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012: 3262-4
Simsek FG, Ulgen Y

Impedance spectroscopy of blood with and without anticoagulants (Acid Citrate Dextrose (ACD), Ethylene Diamine Tetra-acetic Acid (EDTA) and Lithium Heparin (LH)), taken from healthy donors, ages 24-33, are performed in the frequency range 100 kHz-1MHz, using the two electrode impedance measurement method. High frequency data are used in fitting the Cole plot, assuming electrode polarization effects are negligible. It is verified that this is acceptable since the characteristic frequency of the blood is around 1MHz. Cole parameters are used to evaluate the effects of anticoagulants on blood impedance. Interior resistance of red blood cells is not influenced by addition of anticoagulants, whereas plasma resistance, characteristic frequency and depression angle changed. ACD decreases plasma resistance and alpha value of blood, but increases its characteristic frequency. LH significantly increases plasma resistance, but its effect in the characteristic frequency is not clear. No significant effects of EDTA on the electrical properties of blood are detected.
HubMed – depression


Clinical state assessment in bipolar patients by means of HRV features obtained with a sensorized T-shirt.

Filed under: Depression Treatment

Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012: 2240-3
Mariani S, Migliorini M, Tacchino G, Gentili C, Bertschy G, Werner S, Bianchi AM

The aim of this study is to identify parameters extracted from the Heart Rate Variability (HRV) signal that correlate to the clinical state in patients affected by bipolar disorder. 25 ECG and activity recordings from 12 patients were obtained by means of a sensorized T-shirt and the clinical state of the subjects was assessed by a psychiatrist. Features in the time and frequency domain were extracted from each signal. HRV features were also used to automatically compute the sleep profile of each subject by means of an Artificial Neural Network, trained on a control group of healthy subjects. From the hypnograms, sleep-specific parameters were computed. All the parameters were compared with those computed on the control group, in order to highlight significant differences in their values during different stages of the pathology. The analysis was performed by grouping the subjects first on the basis of the depression-mania level and then on the basis of the anxiety level.
HubMed – depression


Implementation of activity-dependent synaptic plasticity rules for a large-scale biologically realistic model of the hippocampus.

Filed under: Depression Treatment

Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012: 1366-9
Robinson BS, Yu GJ, Hendrickson PJ, Song D, Berger TW

A large-scale computational model of the hippocampus should consider plasticity at different time scales in order to capture the non-stationary information processing behavior of the hippocampus more accurately. This paper presents a computational model that describes hippocampal long-term potentiation/depression (LTP/LTD) and short-term plasticity implemented in the NEURON simulation environment. The LTP/LTD component is based on spike-timing-dependent plasticity (STDP). The short-term plasticity component modifies a previously defined deterministic model at a population synapse level to a probabilistic model that can be implemented at a single synapse level. The plasticity mechanisms are validated and incorporated into a large-scale model of the entorhinal cortex projection to the dentate gyrus. Computational expense of the added plasticity was also evaluated and shown to increase simulation time by less than a factor of two. This model can be easily included in future large-scale hippocampal simulations to investigate the effects of LTP/LTD and short-term plasticity in conjunction with other biological considerations on system function.
HubMed – depression


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